RNF165 Inhibitors

NF165, recognized as an E3 ubiquitin-protein ligase, is a member of the RING finger protein family, a group characterized by a distinctive RING domain that facilitates the transfer of ubiquitin to target substrates. This enzymatic activity is central to the ubiquitin-proteasome system, a pivotal cellular machinery for protein degradation and turnover, which maintains protein homeostasis and regulates various cellular processes.

The gene encoding RNF165, through its RING domain, equips the protein with the ability to interact with E2 ubiquitin-conjugating enzymes, enabling the transfer of ubiquitin to lysine residues on substrate proteins. The ubiquitination mediated by RNF165 can signal for proteasomal degradation or modulate other aspects of protein function, such as cellular localization, activity, and interactions, thereby influencing diverse cellular pathways.While detailed functions of RNF165 are relatively obscure, its activity is known to intersect with hormone signaling pathways, notably the androgen receptor (AR) pathway. RNF165 has been implicated in the regulation of AR by potentially serving as a co-regulator, thus impacting AR-dependent transcription and cellular growth responses. This connection is particularly relevant in prostate cancer, where AR signaling is a critical driver of tumor progression.