RNF165 Activators

RNF165, also known as Ring Finger Protein 165, is an E3 ubiquitin-protein ligase encoded by the RNF165 gene in humans. E3 ubiquitin ligases are key components of the ubiquitin-proteasome system, a critical cellular mechanism for protein degradation and turnover. RNF165 plays a pivotal role in tagging specific substrates with ubiquitin, a small regulatory protein that directs them for degradation by the proteasome or modulates their function and localization within the cell.The RNF165 protein contains a characteristic RING (Really Interesting New Gene) finger domain, which is responsible for its ubiquitin ligase activity. The RING finger domain enables RNF165 to interact with E2 ubiquitin-conjugating enzymes and transfer ubiquitin from E2 enzymes to target substrates, a process that often requires recognition of specific degradation signals within those substrates.

RNF165's function in cellular processes is not fully elucidated, but E3 ligases, in general, are involved in various cellular functions, including cell cycle regulation, signal transduction, and immune responses. By controlling the stability and activity of key regulatory proteins, RNF165 could influence these processes. For example, ubiquitination by RNF165 might target proteins involved in apoptosis or cell proliferation for degradation, thus potentially playing a role in cancer biology or other disease mechanisms where these processes are dysregulated.The specificity of RNF165 for its substrates and the pathways it influences remain areas of ongoing research. As with many E3 ubiquitin ligases, understanding the substrates and context-specific roles of RNF165 is crucial for unraveling its biological significance.