Lactacystin CAS: 133343-34-7
Lactacystin is a proteasome inhibitor and cathepsin A inhibitor..

Lactacystin (CAS 133343-34-7)

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Lactacystin is rated 5.0 out of 5 by 2.
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Nombres Alternativos: N-Acetyl-S-{[(2R,3S,4R)-3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinyl]carbonyl}-L-cysteine
Solicitud: Lactacystin is a proteasome inhibitor and cathepsin A inhibitor.
Número de CAS: 133343-34-7
Pureza: >98%
Peso Molecular: 376.43
Fórmula Molecular: C15H24N2O7S
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Lactacystin is a potent and selective irreversible proteasome inhibitor and cathepsin A inhibitor. Lactacystin is a microbial metabolite isolated from Streptomyces first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins. Thus, the effects of this substance are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell. It is shown to inhibit cell proliferation and to induce neurite outgrowth in murine neuroblastoma cell lines such as Neuro 2a.


References

1. Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. U.S.A. 91: 3358-3362. PMID: 8159752

2. Fenteany, G., et al. 1995. Science. 268: 726-731. PMID: 7732382

Uso :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Estado de Materia :
Solid
Forma Derivada :
Streptomyces lactacystinnaeus
Solubilidad :
Soluble in DMSO (~20 mg/ml), water (10 mg/ml), ethanol (~1 mg/ml), methanol, DMF (~20 mg/ml), and PBS pH7.2 (~2 mg/ml).
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
233-235° C (dec.)
Punto de ebullición :
714.88° C at 760 (Predicted)
Densidad :
1.37 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.56 (Predicted)
IC50 :
NF-κB activation : IC50 = 10 µM; chymotrypsin-like activity of 20S proteasome: IC50 = 70 nM (human DLD1 cells ); Splicing factor 3B subunit 3: IC50 = 3.48 µM (human)
Valores de pK :
pKa: 3.11 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
6610292
Número MDL :
MFCD01076525
SMILES :
C[[email protected]@H]1[[email protected]@H]([[email protected]](NC1=O)([[email protected]](C(C)C)O)C(=O)SC[[email protected]@H](C(=O)O)NC(=O)C)O

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Citaciones 1 a 10 de un total de 53

PMID: # 30529563  Barrera-Vázquez, OS. et al. 2019. Virology. 527: 146-158.

PMID: # 30315172  Fornasiero, EF. et al. 2018. Nat Commun. 9: 4230.

PMID: # 29046440  Frabutt, DA.|Wang, B.|Riaz, S.|Schwartz, RC.|Zheng, YH.| et al. 2018. J. Virol. 92:

PMID: # 30275345  Fan, W. et al. 2018. Mol. Cell. Biol.

PMID: # 29596520  Dvorak, KM. et al. 2018. PLoS ONE. 13: e0195278.

PMID: # 29451820  Smelter, DF. et al. 2018. Am. J. Physiol. Heart Circ. Physiol. 314: H1179-H1191.

PMID: # 30538428  Zhu, H. et al. 2018. Drug Des Devel Ther. 12: 4023-4031.

PMID: # 28475871  Benvegnù, S. et al. 2017. Mol. Cell. 66: 358-372.e7.

PMID: # 27974697  Pathangey, LB. et al. 2017. Oncotarget. 8: 10785-10808.

PMID: # 28797057  Farizatto, KLG. et al. 2017. PLoS ONE. 12: e0182895.

Citaciones 1 a 10 de un total de 53
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