Withaferin A CAS: 5119-48-2
MF: C28H38O6
MW: 470.59

Withaferin A (CAS 5119-48-2)

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Withaferin A is rated 5.0 out of 5 by 1.
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Nombres Alternativos: Withaferin A is also known as NSC 101088.
Solicitud: Withaferin A is a steroidal lactone and apoptosis inducer that induces aggregation of vimentin intermediate filaments in cultured endothelial cells and f
Número de CAS: 5119-48-2
Pureza: ≥98%
Peso Molecular: 470.59
Fórmula Molecular: C28H38O6
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Withaferin A, a steroidal lactone originally purified from Withania somnifera, has been shown to have potent antiangiogenesis activity in vivo as well as potent growth inhibitory activities. Withaferin A binds to Vimentin, the intermediate filament (IF) protein, and causes Vimentin filaments to aggregate in vitro. Furthermore, experiments have demonstrated that Withaferin-A induced inhibition of capillary growth in a mouse model of corneal neovascularization in Vimentin-deficient mice. Additional experiments have reported Withaferin A to be a proteasome inhibitor, with a specific primary target for 20S proteasome 5 subunit. Withaferin A demonstrates the potential to inhibit NF B activation by prevention of tumor necrosis factor-activated I B kinase via a thioalkylation-sensitive redox mechanism. In other studies, Withaferin A was also observed to alter cytoskeletal architecture by covalently binding Annexin II and stimulating its basal F-actin cross-linking activity. Another characteristic of Withaferin A that has been noted is its ability to induce regeneration of axons and dendrites and also reconstruct pre and postsynapses in neurons of mice. Withaferin A is also known as NSC 101088, NSC 273757, and 5β,6β-epoxy-4β,22R,27-trihydroxy-1-oxo-δ-lactone-ergosta-2,24-dien-26-oic acid.


References

1. Kuboyama, T. et al. 2005. Br. J. Pharmacol. 144(7): 961-971. PMID: 15711595

2. Falsey, R.R. et al. 2006. Nat. Chem. Biol. 2(1): 33-38. PMID: 16408090

3. Bargagna-Mohan, P. et al. 2007. Chem. Biol. 14(6): 623-634. PMID: 17584610

4. Kaileh, M. et al. 2007. J. Biol. Chem. 282(7): 4253-4264. PMID: 17150968

5. Yang, H. et al. 2007. Mol. Pharmacol. 71(2): 426-437. PMID: 17093135

6. Bargagna-Mohan, P. et al. 2010. J. Biol. Chem. 285(10): 7657-7669. PMID: 20048155

7. Bargagna-Mohan, P. et al. 2013. PLoS ONE. 8(5): e63881. PMID: 23667686

8. Bargagna-Mohan, P. et al. 2015. PLoS ONE. 10(7): e0133399. PMID: 26186445

9. Mohan, R. and Bargagna-Mohan, P. 2016. Meth. Enzymol. 568 : 187-218. PMID: 26795472

Estado de Materia :
Solid
Solubilidad :
Soluble in ethanol, and DMSO.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
252-253° C
Punto de ebullición :
~680.7° C at 760 mmHg (Predicted)
Densidad :
~1.3 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.60 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
RTECS :
KE7288500
PubChem CID :
265237
Indice de Merck :
14: 10048
Número MDL :
MFCD10687098
Registro Beilstein :
5-19-06-00604

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Citaciones 1 a 10 de un total de 16

PMID: # 31226166  Khalilpourfarshbafi, M.|Devi Murugan, D.|Abdul Sattar, MZ.|Sucedaram, Y.|Abdullah, NA.| et al. 2019. PLoS ONE. 14: e0218792.

PMID: # 31409969  2019. Drug Des Devel Ther. 13: 2343-2355.

PMID: # 27324860  Chiba, T. et al. 2016. Sci Rep. 6: 28383.

PMID: # 27308733  Li, X.|Zhu, F.|Jiang, J.|Sun, C.|Zhong, Q.|Shen, M.|Wang, X.|Tian, R.|Shi, C.|Xu, M.|Peng, F.|Guo, X.|Hu, J.|Ye, D.|Wang, M.|Qin, R.| et al. 2016. Autophagy. 12: 1521-37.

PMID: # 26230090  Nishikawa, Y. et al. 2015. PloS one. 10: e0134137.

PMID: # 25444914  Li, X. et al. 2015. Cancer letters. 357: 219-30.

PMID: # 19587106  Widodo, N. et al. 2009. J. Gerontol. A Biol. Sci. Med. Sci. 64: 1031-1038.

PMID: # 17874299  Malik, F. et al. 2007. Apoptosis. 12: 2115-2133.

PMID: # 16841091  Sen, N. et al. 2007. Cell Death Differ. 14: 358-367.

PMID: # 17404115  Widodo, N. et al. 2007. Clin. Cancer Res. 13: 2298-2306.

Citaciones 1 a 10 de un total de 16
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