RMI2 Activators
RMI2, an integral part of the RMI complex, plays a crucial role in preserving genome stability. This protein's significance is particularly emphasized during DNA repair processes, where it aids in ensuring that chromosomal structures remain intact. Chemicals like Mitomycin C and Cisplatin, both known for inducing DNA damage, drive the cell's machinery, including RMI2, into action. By creating DNA crosslinks and adducts, respectively, these chemicals necessitate the intervention of repair pathways where RMI2 is implicated.
On another front, chemicals like Hydroxyurea and Aphidicolin induce replication stress, an event that calls upon various DNA repair components, including RMI2, to restore genomic integrity. Topoisomerase inhibitors like Camptothecin further emphasize the interconnection between DNA damage and RMI2's potential involvement. Furthermore, the action of specific kinase inhibitors, such as the ATM Kinase Inhibitor and VE-822, highlights the broader DNA damage response network in which RMI2 operates.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
DNA crosslinking agent. Crosslinked DNA can engage the Fanconi anemia pathway, thereby possibly influencing RMI2. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Creates DNA adducts. The repair of these adducts can potentially involve the RMI complex, indirectly affecting RMI2. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, leading to DNA replication stress and potentially influencing RMI2 activity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor which interferes with single-strand break repair, potentially implicating RMI2-associated pathways. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
DNA polymerase inhibitor, causing replication stress and potentially affecting RMI2 indirectly. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I leading to DNA damage, potentially involving RMI2 in the repair process. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
Inhibits ATM kinase, a key player in DNA damage response, potentially influencing RMI2. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator which can influence cellular energy status, potentially indirectly affecting DNA repair pathways & RMI2. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubules, inducing cell cycle arrest and DNA damage response, potentially affecting RMI2 indirectly. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Alkylating agent causing DNA damage, which could involve RMI2 in the repair processes. | ||||||