RIMOC1 Inhibitors
Inhibitors of RIMOC1 are varied but interconnected in their ability to disrupt the intricate network of cellular processes that RIMOC1 orchestrates, particularly the regulation of vesicular trafficking and endosome-lysosome fusion. By targeting upstream components of the vesicle formation and transport system, such as specific kinase activities and cytoskeletal dynamics, these inhibitors indirectly exert their effects on RIMOC1. Inhibitors that interfere with tyrosine kinase signaling pathways impede the necessary post-translational modifications and protein interactions essential for the proper function of RIMOC1 in vesicular trafficking. Additionally, compounds that alter cytoskeletal integrity prevent the correct positioning and motility of vesicles, which is crucial for the role of RIMOC1 in the endocytic pathway. Furthermore, the disruption of microtubule and actin networks by specific agents leads to a cascading effect, resulting in the hinderance of RIMOC1's role in vesicle movement and fusion with target compartments.
Additionally, the functionality of RIMOC1 is dependent on the precise regulation of the intracellular environment, such as pH gradients and ionic concentrations within organelles like lysosomes. Certain inhibitors that modify lysosomal pH through the inhibition of proton pumps or by acting as ionophores create a suboptimal environment for RIMOC1-mediated processes. By increasing lysosomal pH, these compounds disrupt the normal fusion events between endosomes and lysosomes, where RIMOC1 has a regulatory function. Other inhibitors also target GTPase activity, which is fundamental to vesicle scission and trafficking, thereby indirectly affecting RIMOC1's interaction with RAB7A in endocytic transport.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A phosphatidylinositol 3-kinase (PI3K) inhibitor that by inhibiting PI3K, wortmannin can disrupt intracellular trafficking processes, which RIMOC1 is involved with by regulating the RAB7A GTPase. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
A GTPase inhibitor that targets dynamin, affecting vesicle scission. Since RIMOC1 functions in vesicle trafficking through RAB7A, dynasore indirectly inhibits RIMOC1-dependent endocytic processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that can interfere with signal transduction pathways involved in vesicle transport and fusion, potentially hindering the RIMOC1-mediated vesicular trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
An ionophore that disrupts lysosomal pH and therefore can indirectly inhibit RIMOC1 activity by affecting lysosomal function and subsequent trafficking pathways where RIMOC1 is implicated. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
A specific inhibitor of V-ATPase that disrupts proton gradients across lysosomal membranes, indirectly affecting RIMOC1 function in endosome-lysosome fusion events. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
An actin polymerization inhibitor that disrupts cytoskeletal dynamics essential for vesicular transport, indirectly impairing RIMOC1-dependent vesicle motility and docking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A microtubule-depolymerizing agent that disrupts intracellular transport pathways, thereby indirectly inhibiting RIMOC1 function in microtubule-dependent vesicle trafficking. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
A pan-caspase inhibitor that can indirectly inhibit RIMOC1 by preventing caspase-mediated cleavage of proteins involved in vesicular transport and fusion, processes in which RIMOC1 participates. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
A weak base that accumulates in lysosomes, raising the pH and interfering with lysosome function, which could indirectly inhibit RIMOC1 activity in lysosome-related trafficking. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
A clathrin-mediated endocytosis inhibitor that indirectly affects RIMOC1 by blocking vesicle formation, a process that RIMOC1 is associated with via its interaction with RAB7A. | ||||||