Ribosomal Protein S6 Inhibitors
Common Ribosomal Protein S6 Inhibitors include, but are not limited to Rapamycin CAS 53123-88-9, AZD8055 CAS 1009298-09-2, Everolimus CAS 159351-69-6, PF 4708671 CAS 1255517-76-0 and LY2228820 CAS 862507-23-1.
Ribosomal Protein S6 inhibitors constitute a class of compounds designed to modulate the activity of ribosomal protein S6 (RPS6), a critical component of the ribosome involved in protein synthesis. RPS6 is phosphorylated by various kinases in response to growth factors, nutrients, and other signals, contributing to the regulation of cell growth, proliferation, and metabolism. Inhibitors targeting RPS6 may work by interfering with its phosphorylation, altering its function, and subsequently influencing the downstream cellular processes in which it participates.
The development of RPS6 inhibitors aims to unravel the intricate mechanisms underlying protein synthesis regulation and its impact on cellular homeostasis. By targeting RPS6, these inhibitors offer insights into the intricate interplay between protein synthesis, cell growth, and signaling pathways. Understanding the role of RPS6 and its modulation through inhibitors can provide valuable knowledge about fundamental cellular processes and their dysregulation in various diseases. The study of RPS6 inhibitors contributes to expanding our understanding of cell biology and has implications for a wide range of scientific and biomedical investigations.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Binds to FKBP12 and inhibits mTORC1, a kinase complex regulating ribosomal S6 phosphorylation, impacting protein synthesis and cell growth. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
Inhibits mTOR kinase activity, leading to decreased ribosomal S6 phosphorylation and subsequent effects on protein synthesis and cell growth. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $128.00 $638.00 | 7 | |
Similar to rapamycin, it inhibits mTORC1, affecting ribosomal S6 phosphorylation and downstream events in protein synthesis and cell growth. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $175.00 $700.00 | 9 | |
A selective inhibitor of S6 kinase (S6K1) that directly targets the phosphorylation of ribosomal protein S6, affecting protein synthesis. | ||||||
LY2228820 | 862507-23-1 | sc-364525 | 5 mg | $191.00 | 1 | |
Inhibits the RSK family of kinases, leading to decreased ribosomal S6 phosphorylation through disruption of S6 kinase activity. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
A dual mTORC1/2 inhibitor that affects ribosomal S6 phosphorylation, modulating protein synthesis and cell growth through mTOR pathway regulation. | ||||||
BI-D1870 | 501437-28-1 | sc-397022 sc-397022A | 1 mg 5 mg | $90.00 $275.00 | 12 | |
Inhibits RSK family kinases, including p70S6K, reducing ribosomal S6 phosphorylation and impacting protein synthesis. | ||||||
SB939 | 929016-96-6 | sc-364610 sc-364610A | 5 mg 50 mg | $205.00 $834.00 | ||
An HDAC inhibitor that can indirectly affect ribosomal S6 phosphorylation by modulating gene expression and signaling pathways. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $240.00 | ||
A potential RNA polymerase I inhibitor that could impact ribosomal biogenesis and subsequent effects on ribosomal protein S6 levels. | ||||||