Ribosomal Protein L9 Inhibitors
The chemical class known as Ribosomal Protein L9 inhibitors would comprise of compounds that either directly or indirectly inhibit the function or stability of the ribosomal protein L9. Since direct inhibitors for this specific protein are not known, the chemical agents listed above target broader aspects of ribosome function or protein synthesis pathways.
These compounds operate at various stages of protein synthesis. Some, such as tetracycline and chloramphenicol, bind to ribosomal subunits to prevent the proper alignment or movement of tRNA and mRNA, thereby disrupting the necessary interactions for protein elongation. Others, like cycloheximide and anisomycin, inhibit the translocation step directly, leading to the cessation of protein synthesis. Actinomycin D and ricin attack the genetic material or rRNA directly, compromising ribosomal integrity and assembly, which are essential for ribosomal protein L9's role in the structure and function of the ribosome. Compounds like sparsomycin and puromycin target the peptidyl transferase center or mimic structural components of the translation process, leading to the disruption of peptide elongation and overall ribosome function. Each of these agents alters ribosomal activity and indirectly impacts the functional contributions of ribosomal protein L9 within the larger ribosomal complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interacts with DNA, preventing RNA synthesis and thereby inhibiting ribosomal RNA transcription, which is crucial for ribosomal assembly and function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Binds to the E-site of the 60S ribosomal subunit, inhibiting the translocation step in protein synthesis, which is essential for the function of all ribosomal proteins, including L9. | ||||||
α-Sarcin | 86243-64-3 | sc-204427 | 1 mg | $462.00 | 6 | |
A ribotoxin that cleaves a specific phosphodiester bond in rRNA, impairing ribosome function and indirectly affecting ribosomal protein L9 by disrupting the ribosomal structure. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Binds to the 30S subunit of the ribosome and inhibits the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site, indirectly influencing ribosomal protein function including that of L9. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Causes premature chain termination during translation by acting as an analog of aminoacyl-tRNA, indirectly affecting ribosomal protein L9 by prematurely dissociating polypeptides from the ribosome. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Binds to the 60S ribosomal subunit, inhibiting peptidyl transferase and thus protein synthesis, which would affect ribosomal protein L9 function indirectly. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Binds to the 50S ribosomal subunit and inhibits bacterial protein synthesis, affecting the ribosome's ability to elongate protein chains, thus indirectly affecting ribosomal protein function. | ||||||
Fusidic acid | 6990-06-3 | sc-215065 | 1 g | $292.00 | ||
Inhibits the turnover of elongation factor G (EF-G) from the ribosome, interfering with translocation of ribosomes along the mRNA, and indirectly affecting the function of all ribosomal proteins, including L9. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Inhibits protein synthesis by blocking the movement of the ribosome along the mRNA, which is essential for the proper function of ribosomal proteins including L9. | ||||||