Ribosomal Protein L23 Activators
Ribosomal Protein L23 activators encompass a range of chemical compounds that indirectly influence the functionality and structural dynamics of the ribosome, thereby modifying the activity of Ribosomal Protein L23. Sparsomycin and Chloramphenicol share a common mechanism of action by targeting the peptidyl transferase center or the translocation process, thereby potentially affecting the conformation and performance of Ribosomal Protein L23. Specifically, these compounds could lead to a compensatory enhancement in L23's interaction with nascent polypeptides or ribosomal RNA, optimizing the protein synthesis process. Puromycin, by mimicking an aminoacyl-tRNA, may inadvertently enhance L23's role in peptide elongation by affecting the termination process. Erythromycin and Fusidic Acid, by binding to the 50S subunit and affecting EF-G dynamics respectively, may promote an environment that accentuates the functional properties of L23 in the peptide exit tunnel formation and elongation cycle.
The activity of Ribosomal Protein L23 is further influenced by compounds that alter ribosomal subunit interactions and integrity. Tetracycline, which disrupts aminoacyl-tRNA binding to the 30S subunit, might indirectly necessitate an enhanced role for L23 in maintaining ribosomal stability. Ricin and α-Sarcin, by damaging the 60S subunit, prompt a structural readjustment that could inadvertently highlight the structural and functional significance of L23 within the altered ribosome. Diphtheria Toxin, through its action on elongation factor 2, indirectly imposes a state where L23 might assume an adapted role to support the compromised elongation process. Lastly, Streptomycin causes mRNA misreading at the 30S subunit, which could lead to an indirect enhancement of L23's role in maintaining the accuracy of translation by stabilizing the ribosomal complex. Together, these activators do not directly bind or modify Ribosomal Protein L23; instead, they create a context that may heighten the protein's innate activity within the ribosome's complex and dynamic environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Puromycin is an antibiotic that causes premature chain termination during translation. It structurally mimics the 3'-end of aminoacyl-tRNA, affecting ribosomal function and thereby influencing the role of Ribosomal Protein L23 in protein synthesis. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol acts by inhibiting the peptidyl transferase activity of the 50S ribosomal subunit. By targeting the 50S subunit, it may indirectly enhance particular aspects of Ribosomal Protein L23 function related to the inhibition of bacterial protein synthesis. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin binds to the 50S ribosomal subunit and may cause an allosteric effect enhancing the activity of Ribosomal Protein L23, as it is part of the 50S subunit involved in nascent peptide exit tunnel formation. | ||||||
Fusidic acid | 6990-06-3 | sc-215065 | 1 g | $292.00 | ||
Fusidic Acid prevents the turnover of elongation factor G (EF-G) from the ribosome. It may indirectly enhance the activity of Ribosomal Protein L23 by stabilizing ribosomal complexes, potentially affecting L23's role in the elongation cycle of protein synthesis. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline binds to the 30S subunit and inhibits the binding of aminoacyl-tRNA to the ribosome. The effect on the 30S subunit can indirectly affect Ribosomal Protein L23 in the 50S subunit by altering ribosome dynamics and function. | ||||||
α-Sarcin | 86243-64-3 | sc-204427 | 1 mg | $462.00 | 6 | |
α-Sarcin is a ribosome inactivating protein that cleaves a specific phosphodiester bond within the ribosomal RNA of the 60S subunit. This can indirectly influence the activity of Ribosomal Protein L23 by affecting ribosomal structure and function. | ||||||
Diphtheria Toxin, CRM Mutant | 92092-36-9 | sc-203924 | 0.25 mg | $652.00 | 1 | |
Diphtheria Toxin catalyzes ADP-ribosylation of elongation factor 2, inhibiting protein synthesis. The alteration in elongation can indirectly modify the functional state of Ribosomal Protein L23, given its role in the ribosome. | ||||||
Streptomycin sulfate | 3810-74-0 | sc-202821 sc-202821A | 10 g 100 g | $92.00 $131.00 | 12 | |
Streptomycin binds to the 30S subunit of the ribosome, causing misreading of mRNA. It indirectly affects Ribosomal Protein L23 by changing the fidelity of protein synthesis, which could alter the dynamics of the 50S subunit where L23 is critical. | ||||||