Rhox4a Inhibitors
Chemical inhibitors of Rhox4a function through various molecular mechanisms to attenuate its role in cellular signaling pathways. Palmitoleic acid, by suppressing the activation of nuclear factor-kappa B (NF-κB), indirectly affects Rhox4a's role in NF-κB related transcriptional activity, leading to a decrease in Rhox4a function. Similarly, PD98059 functions as an inhibitor of the mitogen-activated protein kinase (MAPK/ERK) pathway, which is a cascade that Rhox4a is known to influence. As PD98059 impedes this pathway, it consequently inhibits the role of Rhox4a in processes regulated by MAPK/ERK. Additionally, LY294002 and Wortmannin, both phosphoinositide 3-kinases (PI3K) inhibitors, thwart the PI3K pathway, resulting in an indirect inhibition of Rhox4a function due to the protein's involvement in PI3K-dependent signaling processes.
Furthermore, U0126 and SB203580 target the MEK1/2 and p38 MAPK, respectively, both of which are part of the MAPK/ERK pathway. U0126's inhibition of MEK1/2 and SB203580's targeting of p38 MAPK contributes to the functional inhibition of Rhox4a by attenuating the signaling that Rhox4a is associated with. Meanwhile, SP600125 acts on c-Jun N-terminal kinase (JNK), a kinase involved in regulatory processes where Rhox4a could play a role, and thus inhibits Rhox4a by obstructing essential signaling pathways. On a different angle, Rapamycin interrupts the mammalian target of rapamycin (mTOR) pathway, which is vital for cellular processes that Rhox4a may influence, leading to a decrease in Rhox4a activity. GF109203X inhibits protein kinase C (PKC), which interacts with Rhox4a-involved pathways, thereby inhibiting Rhox4a function. Genistein, a tyrosine kinase inhibitor, disrupts the cellular signaling and regulatory mechanisms that Rhox4a is part of, leading to functional inhibition. Lastly, SN-38 targets DNA replication and cell division processes, and by inhibiting topoisomerase, SN-38 can disrupt cellular processes involving Rhox4a. Trichostatin A, through its inhibition of histone deacetylases, can alter gene expression within pathways where Rhox4a functions, thus affecting Rhox4a's involvement in regulatory networks. Each of these inhibitors, through their respective mechanisms, modulate the activity of Rhox4a within cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitoleic acid | 373-49-9 | sc-205424 sc-205424A sc-205424B sc-205424C sc-205424D | 100 mg 500 mg 1 g 5 g 10 g | $32.00 $132.00 $233.00 $1019.00 $1870.00 | 4 | |
Palmitoleic acid is known to inhibit the activation of nuclear factor-kappa B (NF-κB). Since Rhox4a has been implicated in pathways involving NF-κB in the context of reproductive tissue function, the inhibition of NF-κB by Palmitoleic acid can lead to the functional inhibition of Rhox4a by preventing its role in NF-κB related transcriptional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase (MAPK/ERK), which is a pathway that Rhox4a may influence, particularly in cell growth and differentiation. By inhibiting this pathway, PD98059 can functionally inhibit the role of Rhox4a in cell signaling processes that depend on MAPK/ERK activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of the phosphoinositide 3-kinases (PI3K) pathway, which is involved in cell survival and proliferation. Inhibition of PI3K can indirectly inhibit Rhox4a function by disrupting the signaling pathways that Rhox4a is known to be part of, leading to a decrease in its protein activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 serves as an inhibitor of MEK1/2, key enzymes in the MAPK/ERK pathway. Since Rhox4a is implicated in cellular processes that are regulated by this pathway, the use of U0126 can inhibit the functional role of Rhox4a via attenuation of the MEK/ERK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a known inhibitor of p38 MAPK, a protein kinase involved in the response to stress signals. Rhox4a, which operates within various signaling pathways, could be functionally inhibited by SB203580 through the suppression of p38 MAPK activity, which may be necessary for Rhox4a's functional role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK), which is implicated in regulatory processes that might involve Rhox4a. By inhibiting JNK, SP600125 can functionally inhibit Rhox4a by obstructing the pathways that are essential for the biological roles of Rhox4a. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of PI3K, and by inhibiting this pathway, it can lead to the functional inhibition of Rhox4a. This is because Rhox4a is known to be part of signaling cascades that rely on PI3K for full activation and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR) pathway, which is crucial for cell growth and proliferation. Rhox4a's function can be inhibited by rapamycin through the disruption of mTOR signaling pathways that Rhox4a might influence. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is an inhibitor of protein kinase C (PKC). PKC pathways can interact with signaling pathways that involve Rhox4a, and thus, the inhibition of PKC by GF109203X can lead to the functional inhibition of Rhox4a by blocking the necessary signaling for Rhox4a activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can disrupt various signaling pathways, including those that might involve Rhox4a. The inhibition of tyrosine kinases by Genistein can functionally inhibit Rhox4a's role in cell signaling and regulatory mechanisms. | ||||||