Rhox3c Activators
Reproductive homeobox 3C activators are compounds that influence various cellular signaling pathways to enhance the functional activity of reproductive homeobox 3C. Forskolin, by raising intracellular cAMP, activates PKA, which phosphorylates and activates transcription factors that bind to cAMP response elements and promote reproductive homeobox 3C transcription. EGF and PD 98059 affect the MAPK/ERK pathway, which is crucial for cell cycle progression and differentiation; these compounds indirectly enhance reproductive homeobox 3C expression by activating transcription factors that bind to promoter regions of the gene. Retinoic acid and triiodothyronine (T3) have specific nuclear receptors that upon binding, interact with DNA response elements to directly upregulate reproductive homeobox 3C transcription.
Compounds like 17β-Estradiol and PGE2 function through their respective hormone receptors to regulate gene expression, potentially leading to an increase in reproductive homeobox 3C levels. Sodium butyrate alters chromatin structure, thereby facilitating access to transcription factors and enhancing gene expression, including that of reproductive homeobox 3C. Wnt3a and lithium chloride operate through the Wnt signaling pathway, which plays a pivotal role in gene expression regulation through β-catenin's interaction with TCF/LEF transcription factors; this interaction can upregulate reproductive homeobox 3C.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to retinoic acid receptors (RARs), which then heterodimerize with retinoid X receptors (RXRs) and bind to retinoic acid response elements (RARE) in the DNA, leading to transcriptional activation of genes including reproductive homeobox 3C. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, leading to stabilization and increased activity of β-catenin, which translocates to the nucleus and can promote the expression of downstream targets like reproductive homeobox 3C by acting on Wnt-responsive elements. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
17β-Estradiol binds to estrogen receptors, which can regulate gene expression through estrogen response elements (EREs) in target gene promoters. This regulation can enhance the expression of genes like reproductive homeobox 3C. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that activates PKA and can mimic the action of endogenous cAMP, leading to enhanced transcription of genes under control of PKA, including reproductive homeobox 3C. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
Triiodothyronine binds to thyroid hormone receptors, which then bind to thyroid response elements (TREs) and regulate gene transcription. This binding can enhance the transcription of genes including reproductive homeobox 3C. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 binds to its G-protein coupled receptors (EP receptors), leading to an increase in intracellular cAMP levels and activation of PKA. This can enhance the expression of genes that are regulated by cAMP response elements, including reproductive homeobox 3C. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that leads to hyperacetylation of histones, causing a more relaxed chromatin structure and increased gene transcription. This can enhance the expression of genes such as reproductive homeobox 3C. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a MEK inhibitor that can lead to altered signaling through the ERK pathway, which may result in the modulation of gene expression profiles, including the upregulation of genes such as reproductive homeobox 3C. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, including NF-κB, STAT3, and Wnt/β-catenin. Through these pathways, curcumin can influence the transcription of various genes, potentially including reproductive homeobox 3C. | ||||||