RGL4 Activators
RGL4 (Ral Guanine Nucleotide Dissociation Stimulator Like 4) activators are a class of chemical compounds that play a crucial role in the modulation of cellular signaling pathways. These activators target the RGL4 protein, a member of the Ral family of small GTPases, which are vital components of intracellular signal transduction. RGL4, also known as RGL4/RalGPS2, functions as a guanine nucleotide exchange factor (GEF), facilitating the activation of RalA and RalB GTPases. The activation of these GTPases is essential for regulating various cellular processes, including cell growth, differentiation, migration, and vesicular trafficking. RGL4 Activators act by promoting the exchange of GDP for GTP on RGL4, thereby activating the downstream Ral GTPases and triggering a cascade of molecular events within the cell.
Intracellular signaling pathways mediated by RGL4 and its activators are integral to fundamental cellular functions. Activation of Ral GTPases promotes cytoskeletal rearrangements, which are crucial for processes such as cell migration and membrane trafficking. Additionally, RGL4 and its activators have been implicated in the regulation of cell proliferation, cell adhesion, and membrane dynamics, all of which are central to the overall functioning of cells in various tissues and organs.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-Triphosphate, Disodium Salt | 56001-37-7 | sc-295030 sc-295030A | 50 mg 250 mg | $163.00 $321.00 | ||
GTP is a natural activator for RGL4. | ||||||
Guanylyl Imidodiphosphate | 148892-91-5 | sc-215113 sc-215113A | 5 mg 25 mg | $189.00 $605.00 | ||
GppNHp is a non-hydrolyzable analog of GTP and can activate RGL4 by mimicking GTP. | ||||||
8-pCPT-2′-O-Me-cAMP | 634207-53-7 | sc-257020 | 1 mg | $300.00 | 5 | |
This is a cAMP analog that has been shown to activate RGL4 indirectly by modulating cAMP-dependent signaling pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a potent phosphatase inhibitor that can activate RGL4 by preventing the dephosphorylation of critical regulatory sites. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Like sodium orthovanadate, sodium fluoride can inhibit phosphatases and activate RGL4 indirectly. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin is a calcium-binding protein that can activate RGL4 by mediating calcium-dependent signaling pathways. | ||||||
1,2-Dioleoyl-sn-glycerol | 24529-88-2 | sc-204958 sc-204958A | 10 mg 25 mg | $114.00 $170.00 | ||
DAG is a lipid molecule that can activate RGL4 by regulating lipid-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), and PKC activation can indirectly stimulate RGL4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased levels of cAMP and potential activation of RGL4 through cAMP-dependent pathways. | ||||||