Molecular structure of Guanylyl Imidodiphosphate, CAS Number: 148892-91-5
Guanylyl Imidodiphosphate (CAS 148892-91-5)
Alternate Names:
Guanylyl Imidodiphosphate is also known as GMP-PNP.
Application:
Guanylyl Imidodiphosphate is a non-hydrolyzable GTP analog ARF (ADP-ribosylation factor) activator.
CAS Number:
148892-91-5
Purity:
≥85%
Molecular Weight:
588.14
Molecular Formula:
C10H14N6Na3O13P3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanylyl Imidodiphosphate is the preferred GTP analog to activate ADP-ribosylation factor. Guanylyl Imidodiphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, Guanylyl Imidodiphosphate is often used in studies of protein synthesis. Guanylyl Imidodiphosphate has linkage to Non-hydrolyzable analogs of GTP.
Guanylyl Imidodiphosphate (CAS 148892-91-5) References
- Decreased striatal dopamine D1 receptor-stimulated adenylyl cyclase activity in human methamphetamine users. | Tong, J., et al. 2003. Am J Psychiatry. 160: 896-903. PMID: 12727693
- Regional distribution of guanine nucleotide-sensitive and guanine nucleotide-insensitive vasoactive intestinal peptide receptors in rat brain. | Hill, JM., et al. 1992. Neuroscience. 48: 925-32. PMID: 1321366
- Intraneuronal guanylyl-imidodiphosphate injection mimics long-term synaptic hyperpolarization in Aplysia. | Treistman, SN. and Levitan, IB. 1976. Proc Natl Acad Sci U S A. 73: 4689-92. PMID: 188052
- [Regulation by cations of adenylate cyclase activity in chicken tissues]. | Goffenberg, SI. and Zhuravlev, IV. 1988. Biokhimiia. 53: 1214-9. PMID: 3179368
- GTP enhances inositol trisphosphate-stimulated Ca2+ release from rat liver microsomes. | Dawson, AP. 1985. FEBS Lett. 185: 147-50. PMID: 3873359
- The reversal of the Gpp(NH)p-activated state of adenylate cyclase by GTP and hormone is by the 'collision coupling' mechanism. | Arad, H., et al. 1981. J Biol Chem. 256: 1593-7. PMID: 6257678
- Chronic effects of 6-hydroxydopamine and reserpine on myocardial adenylate cyclase. | Chiu, TH. 1978. Eur J Pharmacol. 52: 385-8. PMID: 729648
- [3H]-quinelorane binds to D2 and D3 dopamine receptors in the rat brain. | Gackenheimer, SL., et al. 1995. J Pharmacol Exp Ther. 274: 1558-65. PMID: 7562534
- Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. | Moodie, SA., et al. 1993. Science. 260: 1658-61. PMID: 8503013
- Karyopherin beta2 mediates nuclear import of a mRNA binding protein. | Bonifaci, N., et al. 1997. Proc Natl Acad Sci U S A. 94: 5055-60. PMID: 9144189
- Synergistic activation of adenylate cyclase by guanylyl imidophosphate and epinephrine. | Sevilla, N., et al. 1976. Biochemistry. 15: 3493-9. PMID: 952872
- The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells. | Francken, BJ., et al. 1998. Eur J Pharmacol. 361: 299-309. PMID: 9865521
Activator of:
ARF, and RGL4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanylyl Imidodiphosphate, 5 mg | sc-215113 | 5 mg | $193.00 | |||
Guanylyl Imidodiphosphate, 25 mg | sc-215113A | 25 mg | $617.00 |