Date published: 2025-10-25

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RGL4 Inhibitors

RGL4 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the RGL4 protein, which stands for "Ras guanine nucleotide-releasing protein-like 4." RGL4 is a member of the Ras superfamily of small GTPases, which play pivotal roles in cellular signaling pathways by regulating various cellular processes, including cell growth, proliferation, and differentiation. While RGL4 is relatively less studied compared to other Ras superfamily members, it is recognized for its potential involvement in intracellular signaling cascades, particularly those associated with GTPase activation and downstream signaling events. Inhibitors designed to target RGL4 are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this protein.

The development of RGL4 inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with RGL4 and modulate its activity within the context of cellular signaling pathways. By inhibiting RGL4, these compounds can potentially disrupt its role in mediating GTPase activation or downstream signaling events, affecting cellular processes dependent on proper Ras superfamily function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Lonafarnib

193275-84-2sc-482730
sc-482730A
5 mg
10 mg
$173.00
$234.00
(0)

Lonafarnib is a farnesyltransferase inhibitor which could prevent proper localization and function of Ras proteins, possibly affecting related GEF activity.

Tipifarnib

192185-72-1sc-364637
10 mg
$720.00
(0)

Tipifarnib inhibits farnesyl protein transferase, potentially altering Ras function and associated signaling, which could indirectly affect GEFs like RGL4.

GGTI 298

1217457-86-7sc-361184
sc-361184A
1 mg
5 mg
$189.00
$822.00
2
(1)

GGTI-298 inhibits geranylgeranyltransferase, potentially impacting Ras localization and function, which could indirectly modify GEF activity.

Zoledronic acid, anhydrous

118072-93-8sc-364663
sc-364663A
25 mg
100 mg
$90.00
$251.00
5
(0)

Zoledronic acid inhibits farnesyl pyrophosphate synthase, which may indirectly affect Ras prenylation and GEFs involved in Ras signaling.

Manumycin A

52665-74-4sc-200857
sc-200857A
1 mg
5 mg
$215.00
$622.00
5
(1)

Manumycin A is a farnesyltransferase inhibitor, potentially affecting the post-translational modification of Ras and consequently GEFs like RGL4.

Cysmethynil

851636-83-4sc-500804
sc-500804A
5 mg
10 mg
$133.00
$253.00
1
(0)

Cysmethynil inhibits isoprenylcysteine carboxyl methyltransferase (ICMT), potentially impacting Ras processing and related GEF functions.

GGTI-2133

1217480-14-2sc-221668
sc-221668A
1 mg
5 mg
$215.00
$620.00
2
(0)

GGTI-2133 inhibits geranylgeranyltransferase I, potentially affecting the membrane association of Ras, which may have consequences for GEFs like RGL4.