RGL4 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the RGL4 protein, which stands for "Ras guanine nucleotide-releasing protein-like 4." RGL4 is a member of the Ras superfamily of small GTPases, which play pivotal roles in cellular signaling pathways by regulating various cellular processes, including cell growth, proliferation, and differentiation. While RGL4 is relatively less studied compared to other Ras superfamily members, it is recognized for its potential involvement in intracellular signaling cascades, particularly those associated with GTPase activation and downstream signaling events. Inhibitors designed to target RGL4 are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this protein.
The development of RGL4 inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with RGL4 and modulate its activity within the context of cellular signaling pathways. By inhibiting RGL4, these compounds can potentially disrupt its role in mediating GTPase activation or downstream signaling events, affecting cellular processes dependent on proper Ras superfamily function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lonafarnib | 193275-84-2 | sc-482730 sc-482730A | 5 mg 10 mg | $173.00 $234.00 | ||
Lonafarnib is a farnesyltransferase inhibitor which could prevent proper localization and function of Ras proteins, possibly affecting related GEF activity. | ||||||
Tipifarnib | 192185-72-1 | sc-364637 | 10 mg | $720.00 | ||
Tipifarnib inhibits farnesyl protein transferase, potentially altering Ras function and associated signaling, which could indirectly affect GEFs like RGL4. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $189.00 $822.00 | 2 | |
GGTI-298 inhibits geranylgeranyltransferase, potentially impacting Ras localization and function, which could indirectly modify GEF activity. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic acid inhibits farnesyl pyrophosphate synthase, which may indirectly affect Ras prenylation and GEFs involved in Ras signaling. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Manumycin A is a farnesyltransferase inhibitor, potentially affecting the post-translational modification of Ras and consequently GEFs like RGL4. | ||||||
Cysmethynil | 851636-83-4 | sc-500804 sc-500804A | 5 mg 10 mg | $133.00 $253.00 | 1 | |
Cysmethynil inhibits isoprenylcysteine carboxyl methyltransferase (ICMT), potentially impacting Ras processing and related GEF functions. | ||||||
GGTI-2133 | 1217480-14-2 | sc-221668 sc-221668A | 1 mg 5 mg | $215.00 $620.00 | 2 | |
GGTI-2133 inhibits geranylgeranyltransferase I, potentially affecting the membrane association of Ras, which may have consequences for GEFs like RGL4. | ||||||