RFC2 inhibitors belong to a specific category of chemical compounds that have garnered attention in the field of molecular biology and DNA replication research. RFC2, or Replication Factor C Subunit 2, is a critical component of the Replication Factor C (RFC) complex, which plays an indispensable role in DNA replication, a fundamental process essential for the faithful duplication of genetic material during cell division. The term RFC2 inhibitors refers to a group of molecules meticulously designed to selectively target and modulate the activity of RFC2. These inhibitors serve as invaluable tools in laboratory investigations, enabling researchers to explore the intricate molecular functions and cellular processes associated with RFC2.
RFC2 inhibitors typically function by interfering with the binding of RFC2 to other subunits of the RFC complex or DNA, thereby disrupting the normal process of DNA replication. This interference can lead to alterations in DNA synthesis, impacting various aspects of genome integrity and cell proliferation. Researchers employ RFC2 inhibitors to gain insights into the physiological roles and molecular interactions of RFC2 within cells, aiming to advance our understanding of the fundamental mechanisms involved in DNA replication. Through the study of RFC2 inhibitors, scientists seek to unravel the complexities of DNA replication machinery, genome maintenance, and the broader field of molecular biology, contributing to our knowledge of how cells accurately duplicate their genetic information and ensure genetic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a DNA polymerase inhibitor that could potentially limit the need for RFC2 in the DNA replication process, thereby reducing its expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, potentially resulting in reduced expression of replication-associated proteins like RFC2. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, may disrupt DNA replication dynamics, indirectly influencing RFC2 expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases which may lead to cell cycle arrest and reduced expression of genes involved in DNA replication, like RFC2. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C crosslinks DNA, potentially affecting DNA replication and consequently the expression of RFC2. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor that could influence cell cycle progression and indirectly decrease RFC2 expression. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Similar to roscovitine, olomoucine is a CDK inhibitor that may modulate cell cycle-related gene expression, including RFC2. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
Thymidine is a nucleoside analogue that, when excessively present, can cause an imbalance in nucleotide pools and possibly downregulate DNA replication proteins like RFC2. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to decreased deoxyribonucleotide levels and potentially reduced expression of replication factors like RFC2. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts that can interfere with DNA replication machinery, potentially diminishing the need for factors such as RFC2. | ||||||