RERG Activators
RERG Activators encompass a range of chemical compounds that indirectly boost the functional activity of RERG through multiple signaling pathways. Compounds like Forskolin and Ionomycin elevate secondary messengers within the cell, namely cAMP and calcium, which can activate protein kinases like PKA and calmodulin-dependent kinases, respectively. This activation leads to phosphorylation events that can enhance the signaling pathways RERG is part of, particularly those regulating cell differentiation and migration. Similarly, the diester PMA activates PKC, which is known to engage in signaling cascades that could amplify RERG's role in cellular processes.
Sphingosine-1-phosphate acts through lipid signaling receptors to exert downstream effects, potentially bolstering RERG's involvement in cell motility and angiogenesis. EGCG, through its kinase inhibitory action, alters intracellular signaling dynamics, which may reduce negative regulation and enhance RERG's signaling involvement. The calcium ionophore A23187 directly raises cytosolic calcium levels, which can activate calcium-dependent signaling crucial for processes like cell adhesion, where RERG may play a role. Genistein, by inhibiting tyrosine kinases, potentially enables a more significant contribution of RERG in its associated signaling networks.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene that is produced by the Indian Coleus plant. Forskolin activates adenylate cyclase, which increases intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and thereby enhance the activity of RERG by promoting its signaling pathways. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Increased calcium can activate calmodulin-dependent kinase, which can further enhance the signaling pathways that RERG is involved in, leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and is a potent activator of protein kinase C (PKC). PKC activation can lead to the enhancement of RERG's role in signaling pathways, particularly those related to cellular growth and differentiation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a signaling lipid that can activate sphingosine-1-phosphate receptors. This activation can lead to downstream effects that enhance RERG activity, particularly in pathways associated with cell migration and angiogenesis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a type of catechin found in green tea. It acts as an antioxidant and has been shown to inhibit certain types of kinases, which can reduce competitive inhibition and enhance RERG signaling pathways involved in cell survival and metabolism. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that selectively transports calcium (Ca2+) across cell membranes. By increasing intracellular Ca2+, it can activate calcium-dependent signaling pathways, potentially enhancing the activity of RERG in processes such as cell adhesion and migration. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy products that functions as a tyrosine kinase inhibitor. By inhibiting tyrosine kinase activity, Genistein can reduce competitive signaling and enhance RERG's role in cell growth and differentiation pathways. | ||||||