REM2 Activators
Akt1 Activators encompass a group of compounds that engage various signaling pathways, culminating in the enhanced activity of Akt1, a serine/threonine-specific protein kinase playing a central role in cellular survival, metabolism, and growth. Insulin is a primary activator of Akt1, engaging the PI3K/AKT signaling axis; upon receptor binding, PI3K is recruited, generating PIP3 and facilitating Akt1 activation via phosphorylation at the membrane.
Similarly, growth factors like IGF-1, PDGF, EGF, and FGF initiate their respective receptor tyrosine kinase signaling cascades, ultimately activating PI3K and promoting PIP3 formation, a prerequisite for Akt1 recruitment and phosphorylation. The lipid-derived messenger Sphingosine-1-phosphate and Lysophosphatidic acid both activate G protein-coupled receptors, leading to PI3K recruitment and subsequent Akt1 activation. Moreover, Thapsigargin and TGF-beta, through SERCA inhibition and TGF-beta receptor activation, respectively, stimulate pathways that converge on PI3K/Akt1 signaling, reinforcing Akt1 phosphorylation and activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and thereby enhance the activity of REM2, as PKA-mediated phosphorylation is known to regulate the activity and localization of several proteins within the same family as REM2. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation can lead to phosphorylation events that enhance REM2's functional activity or influence its interactions within cellular signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially altering calcium-dependent protein kinase (such as CaMK) activity which can modulate REM2 activity as CaMKs are capable of phosphorylating proteins related to REM2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), and PKC-mediated phosphorylation can enhance the activity of proteins like REM2 by changing their conformation or promoting their interaction with other cellular components. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels via G protein-coupled receptor signaling, indirectly leading to PKA activation which may enhance REM2 activity through phosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator that can modulate the activity of proteins related to the JNK pathway. JNK pathway activation can lead to altered phosphorylation states that may indirectly enhance REM2 function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of various proteins, which could enhance REM2 activity by preventing its dephosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases, which leads to an increase in protein phosphorylation. Enhanced phosphorylation may indirectly activate REM2 by preventing its dephosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium, which can activate calcium-dependent signaling pathways and proteins, potentially resulting in enhanced activity of REM2 via calcium-dependent phosphorylation or regulation of its partners. | ||||||