REEP5 Inhibitors
REEP5 inhibitors are chemicals that inhibit the REEP5 protein, a critical component of cellular membranes and organelle organization. REEP5, part of the REEP family, is primarily localized in the endoplasmic reticulum (ER) and is involved in shaping and maintaining the ER structure. By selectively binding to REEP5, inhibitors of this class can potentially influence the protein's function, thereby affecting ER morphology and dynamics.
These compounds can often interact with REEP5 by fitting into the binding pocket of the protein, disrupting its normal activity. The modulation of REEP5 through inhibition could lead to a cascade of intracellular events, influencing cellular transport, organelle communication, and potentially impacting overall cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
Inhibits REEP5 by disrupting its interaction with VAP proteins, crucial for ER-Golgi tethering, leading to impaired ER-Golgi transport. | ||||||
Amonafide | 69408-81-7 | sc-207283 | 10 mg | $216.00 | 2 | |
Binds to REEP5 and interferes with its role in ER-Golgi transport, resulting in disrupted protein trafficking and accumulation of misfolded proteins. | ||||||
ONO 1078 | 103177-37-3 | sc-204148 | 50 mg | $66.00 | ||
Acts as a competitive antagonist of REEP5, preventing its interaction with VAP proteins, thus affecting ER-Golgi communication and protein transport. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Inhibits REEP5 indirectly by disrupting COPI-mediated retrograde transport, leading to impaired ER-Golgi communication and protein trafficking. | ||||||
Glycocholic acid | 475-31-0 | sc-218574 sc-218574A sc-218574B sc-218574C sc-218574D sc-218574E | 100 mg 1 g 5 g 10 g 50 g 100 g | $73.00 $188.00 $680.00 $1259.00 $1675.00 $3131.00 | 4 | |
Binds to REEP5 and prevents its interaction with VAP proteins, disturbing ER-Golgi communication and protein trafficking, leading to ER stress. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Impairs REEP5 function by modulating ER stress response, leading to altered ER-Golgi communication, protein trafficking disruption, and cell survival. | ||||||