RecQL5 Activators
RecQL5 activators belong to a distinctive chemical class that specifically targets the RecQL5 helicase enzyme, a member of the RecQ family of DNA helicases. These small molecules are designed to modulate the activity of RecQL5, a key player in DNA metabolism and maintenance. RecQL5, encoded by the RECQL5 gene, plays a crucial role in the resolution of DNA structures during processes such as replication, recombination, and repair. The RecQL5 enzyme possesses both helicase and ATPase activities, enabling it to unwind DNA structures and participate in the resolution of complex DNA intermediates.
RecQL5 activators exert their influence by interacting with the RecQL5 enzyme, presumably affecting its conformation or enhancing its catalytic activities. By doing so, these compounds have the potential to modulate various cellular processes that involve RecQL5, ultimately influencing DNA integrity and stability. The specific mechanisms through which RecQL5 activators interact with the enzyme and the downstream effects of this modulation are areas of ongoing research. Understanding the precise molecular interactions between these activators and RecQL5 could shed light on the intricate regulatory networks governing DNA maintenance and repair in cells. Continued exploration of RecQL5 activators may offer insights into fundamental cellular processes and contribute to our understanding of how DNA helicases can be selectively targeted for manipulation in various biological contexts.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Activates RECQL5 indirectly by inhibiting ATM kinase, a part of the DNA damage response pathway. Commonly found in coffee. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Indirectly influences RECQL5 by activating ATR kinase, a key player in cellular responses to DNA damage. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Inhibits PARP, affecting DNA repair pathways and potentially influencing RECQL5 indirectly. Used in cancer therapy. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
While known as a DNA-PK inhibitor, specific activators for DNA-PK are less common, potentially affecting RECQL5 indirectly. | ||||||
PRIMA-1MET | 5291-32-7 | sc-361295 sc-361295A | 10 mg 25 mg | $153.00 $325.00 | 5 | |
Activates p53, a protein interacting with RECQL5 in DNA repair processes, potentially influencing RECQL5 indirectly. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Indirectly influences RECQL5 by activating MAPK pathways, which play a role in cellular responses to DNA damage. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
Activates AKT, potentially influencing RECQL5 indirectly as AKT is involved in various cellular processes, including DNA repair. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, but analogs with activating properties are under investigation, potentially influencing RECQL5 indirectly. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Alters histone acetylation as an HDAC inhibitor, potentially impacting DNA repair processes and RECQL5 indirectly. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Induces DNA damage, potentially affecting the DNA repair pathways in which RECQL5 participates. Used in platinum-based chemotherapy. | ||||||