RecA Inhibitors
RecA Inhibitors are related to DNA repair pathways and include DNA-damaging agents that could indirectly influence the function of RecA, a protein crucial for homologous recombination and DNA repair in bacteria. Mitomycin C, Ciprofloxacin, Norfloxacin, Nalidixic Acid, Bleomycin, Doxorubicin, Etoposide (VP-16), and Camptothecin are agents that induce various types of DNA damage, including crosslinks, strand breaks, and replication stress. These DNA lesions may necessitate the involvement of RecA for repair through homologous recombination. Hydroxyurea and Methyl methanesulfonate affect DNA synthesis and integrity, potentially leading to conditions that require RecA-mediated repair processes. Aflatoxin B1-13C,d3 is a known mutagen that causes DNA adducts and lesions, invoking RecA-dependent repair mechanisms.
UV Radiation is a physical DNA-damaging agent causing lesions like thymine dimers, often repaired through pathways involving RecA. These compounds and conditions serve as tools for studying the mechanisms of DNA repair and the role of proteins like RecA in maintaining genomic stability. While they do not target RecA directly, their effects on inducing DNA damage or impacting repair pathways provide a context for understanding the functional role of RecA in bacterial DNA repair processes. Studying these agents helps in exploring the intricacies of homologous recombination and the cellular response to genomic stress, highlighting the importance of proteins like RecA in preserving genetic integrity under various stress conditions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Induces DNA crosslinks, potentially requiring RecA-mediated homologous recombination for repair. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $43.00 | 8 | |
A fluoroquinolone antibiotic that induces DNA damage, potentially increasing the demand for RecA-mediated repair. | ||||||
Norfloxacin | 70458-96-7 | sc-215586 | 10 g | $125.00 | 1 | |
Similar to ciprofloxacin, it causes DNA damage that may necessitate RecA function for repair. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, leading to reduced deoxyribonucleotide pools and potentially affecting DNA repair processes involving RecA. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Causes DNA strand breaks, potentially necessitating RecA-dependent repair pathways. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline anticancer agent that causes DNA damage, potentially involving RecA in the repair process. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase II inhibitor, potentially increasing the frequency of DNA double-strand breaks and impacting RecA function. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Alkylates DNA, leading to damage that may involve RecA in the repair process. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits topoisomerase I, causing DNA breaks, which may increase the demand for RecA-mediated repair. | ||||||