RDH8 Activators
RDH8 activators are a class of chemical compounds known for their ability to modulate the activity of the enzyme retinol dehydrogenase 8 (RDH8). RDH8 is a key enzyme involved in the visual cycle, which is the process by which the retina converts light into electrical signals that can be interpreted by the brain. Specifically, RDH8 catalyzes the conversion of retinol (vitamin A alcohol) to retinal (vitamin A aldehyde), an essential step in the regeneration of the visual pigment rhodopsin. By activating RDH8, these compounds can potentially enhance the efficiency of the visual cycle, leading to improved visual function.
The mechanism by which RDH8 activators exert their effects is not yet fully understood, but it is believed to involve the modulation of RDH8 enzyme activity. By binding to RDH8, these compounds may stabilize the enzyme in its active conformation, thereby increasing its catalytic activity and promoting the conversion of retinol to retinal. This, in turn, could lead to faster regeneration of rhodopsin and improved sensitivity to light.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $126.00 $372.00 | 7 | |
A direct substrate for RDH8, its increased levels necessitate elevated RDH8 activity for conversion to retinal. | ||||||
9-cis Retinal | 514-85-2 | sc-207217 | 10 mg | $405.00 | 2 | |
Although not a direct activator, the presence of this retinal isomer might necessitate rebalancing of retinoid metabolism, driving RDH8 to process more retinol to maintain equilibrium. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
By modulating retinoid receptor activity, it can create a cellular demand for more retinol to retinal conversion, indirectly increasing RDH8 activity. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
Metabolized to tazarotenic acid. This process can skew retinoid homeostasis, driving RDH8 activity to restore balance by converting more retinol to retinal. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $54.00 $245.00 | 6 | |
By binding RXRs, it alters retinoid homeostasis, potentially increasing the need for RDH8's conversion of retinol to retinal. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $148.00 | 1 | |
Being a retinoid, its presence can imbalance retinoid levels, creating a situation where RDH8 may need to process more retinol to maintain homeostasis. | ||||||
Adapalene | 106685-40-9 | sc-203803 sc-203803A | 10 mg 50 mg | $65.00 $325.00 | 2 | |
Being a retinoid analog, its presence can affect retinoid balance in cells, potentially driving RDH8 to convert more retinol to retinal. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $74.00 $118.00 | 8 | |
Alters retinoid metabolism, potentially creating a state where RDH8's activity is favored to balance retinol levels. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
Being a natural retinoid, its cellular presence can favor conditions that necessitate increased RDH8 activity for retinol conversion. | ||||||