RBM12B Activators
RBM12B Activators operate through a diverse range of mechanisms, each with the capability to enhance gene expression or cellular processes that may indirectly lead to the activation of RBM12B. Retinoic acid and beta-estradiol interact with nuclear hormone receptors to modulate gene expression, potentially including genes that encode RNA splicing factors. Epigallocatechin gallate can activate the Nrf2 pathway, which regulates a wide array of genes, including potentially those involved in RNA metabolism. Cyclic AMP analogs such as forskolin and dibutyryl-cAMP act on adenylate cyclase or mimic cAMP, leading to activation of protein kinase A (PKA). PKA can then phosphorylate various targets within the cell, resulting in altered gene expression. Phorbol esters like PMA activate protein kinase C (PKC), which is involved in transducing signals that can lead to transcriptional regulation, potentially upregulating splicing factors.
Sodium butyrate change chromatin dynamics, making it easier for transcription machinery to access DNA and potentially increasing the transcription of genes involved in RNA splicing. Lithium chloride activates the Wnt signaling pathway, which can lead to changes in the transcriptional program of a cell, possibly affecting genes related to RNA processing. Finally, plant-derived hormones such as kinetin, zeatin, and synthetic cytokinins like 6-benzylaminopurine influence cellular growth and gene expression, offering potential indirect upregulation of RNA processing factors, including RBM12B.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Induces gene expression changes via retinoic acid receptors, which can lead to the activation of genes involved in RNA splicing, potentially influencing RBM12B. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A green tea polyphenol that activates cellular antioxidant responses through Nrf2 signaling, which can influence gene expression patterns, including those related to RNA processing. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase to increase cAMP levels, thereby activating PKA. PKA can phosphorylate proteins involved in gene transcription regulation, possibly affecting RBM12B. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC) which is involved in cell signaling leading to transcriptional regulation; this may upregulate splicing factors including RBM12B. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cell-permeable cAMP analog that activates cAMP-dependent pathways, potentially increasing transcription of genes including those for RNA splicing factors like RBM12B. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Binds to estrogen receptors, activating genes involved in various biological processes including RNA processing; could enhance RBM12B expression. | ||||||
Kinetin | 525-79-1 | sc-207780 sc-207780A | 1 g 5 g | $37.00 $47.00 | ||
A cytokinin plant hormone that, when applied to cells, can stimulate cellular division and influence gene expression; could theoretically upregulate RNA splicing factors. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor leading to an open chromatin state that could increase the expression of genes involved in RNA splicing and regulation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Can activate Wnt signaling, leading to changes in gene expression which might upregulate RNA processing genes, potentially influencing RBM12B expression. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Phosphodiesterase inhibitor that raises intracellular cAMP levels, possibly leading to altered gene expression and activity of RNA binding proteins. | ||||||