RBBP9 Activators

Retinoblastoma binding protein 9 (RBBP9) is a protein encoded by the RBBP9 gene in humans. It is known to interact with the retinoblastoma (Rb) protein, a crucial tumor suppressor that regulates the cell cycle and blocks excessive cell growth. However, RBBP9 is also known to possess oncogenic properties, highlighting its complex role in cellular function and disease.RBBP9 belongs to the family of hydrolases and is known to catalyze the hydrolysis of O-glycosyl compounds. One of its crucial functions is the regulation of cell growth and the cell cycle. Through its interaction with Rb, RBBP9 can disrupt the normal cell cycle control exerted by the Rb protein, potentially leading to uncontrolled cell growth.

The protein is known to be overexpressed in several types of cancers, including pancreatic, lung, and colorectal cancers. Its overexpression has been associated with poor prognosis in pancreatic cancer, suggesting a role in cancer progression. RBBP9 is thought to contribute to oncogenesis by promoting cell proliferation, migration, and invasion, as well as by inhibiting apoptosis, or programmed cell death.In addition to its role in cancer, RBBP9 is also involved in the response to DNA damage. It plays a role in the DNA damage checkpoint, a mechanism that halts the cell cycle to allow for DNA repair or to trigger apoptosis in case of severe damage.In summary, RBBP9 is a protein with significant roles in cell cycle regulation, DNA damage response, and oncogenesis.