RAP80 Inhibitors
The inhibitors listed above target various components of DNA damage response and repair pathways, which could indirectly influence RAP80 activity. Given RAP80's critical role in homologous recombination and DNA repair, modulation of these pathways is relevant for understanding its function and potential regulation.
PARP inhibitors disrupt key DNA repair mechanisms, potentially impacting pathways where RAP80 functions. ATM and ATR inhibitors, by affecting the cellular response to DNA damage, might indirectly impact RAP80's role in DNA repair. DNA-PK inhibitors and BRCA1/2 inhibitors can modulate competing or complementary pathways to homologous recombination, potentially influencing RAP80. CHK1 and WEE1 inhibitors disrupt cell cycle checkpoints, which could affect RAP80's function in the context of DNA repair. Inhibitors of RAD51 and proteins like HSP90, Topoisomerase, and HDAC can influence the dynamics of DNA repair, potentially impacting RAP80's activity. PI3K/Akt/mTOR inhibitors might affect cell growth and survival pathways, indirectly influencing DNA repair processes involving RAP80.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitors can disrupt DNA damage repair pathways, potentially impacting RAP80's role in homologous recombination. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
ATM inhibitors affect the response to DNA damage, which might indirectly impact RAP80's function in DNA repair. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
ATR inhibitors can also affect DNA damage response mechanisms, potentially impacting RAP80 function. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
DNA-PK inhibitors can affect non-homologous end joining, a competing pathway to homologous recombination, potentially influencing RAP80 activity. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Inhibitors of BRCA1/2, key proteins in homologous recombination, might indirectly impact RAP80's function. | ||||||
SCH 900776 | 891494-63-6 | sc-364611 sc-364611A | 5 mg 10 mg | $255.00 $338.00 | ||
CHK1 inhibitors can disrupt cell cycle checkpoints involved in the DNA damage response, potentially affecting RAP80 activity. | ||||||
RAD51 Inhibitor B02 | 1290541-46-6 | sc-507533 | 10 mg | $95.00 | ||
RAD51 is crucial for homologous recombination; its inhibition could indirectly influence RAP80's role in DNA repair. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
HSP90 inhibitors might affect the stability of proteins involved in DNA repair, potentially impacting RAP80. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Topoisomerase inhibitors can affect DNA dynamics and stability, potentially influencing RAP80's role in DNA repair. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
HDAC inhibitors can alter chromatin structure, potentially affecting DNA repair processes involving RAP80. | ||||||