RAIN Activators
Ras Interacting Protein 1 (RIN1) is a protein that plays a significant role in cellular signaling pathways, particularly those involving the Ras family of GTPases, which are known for their impact on cell proliferation, differentiation, and survival. RIN1 acts as a molecular link between various signaling cascades and biological processes, highlighting its importance in cell biology.The primary function of RIN1 is to modulate the activity of Ras, a well-known proto-oncogene. It does this through its Ras-binding domain (RBD), which interacts directly with Ras proteins. This interaction is crucial for the activation or inhibition of downstream signaling pathways, depending on the cellular context. These pathways are involved in key cellular functions such as growth, differentiation, and apoptosis.
RIN1 also possesses a Vps9 domain, which is known to have guanine nucleotide exchange factor (GEF) activity for the Rab5 family of small GTPases. This activity is important for endocytosis and early endosome dynamics, linking RIN1 to vesicular trafficking processes within the cell.Additionally, RIN1 interacts with other proteins, such as ABL tyrosine kinases. This interaction can lead to the activation of ABL and subsequent modulation of actin cytoskeleton dynamics, which is vital for processes like cell migration and cytoskeletal rearrangement.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can modulate signaling pathways leading to the activation of RAS superfamily proteins like RAIN. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can modulate signaling pathways involving RAS proteins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a downstream effector of RAS signaling, potentially influencing RAIN expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, a key player in the RAS pathway, which could affect RAIN expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, another pathway that can interact with RAS signaling, potentially influencing RAIN expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is involved in the MAPK/ERK pathway linked to RAS signaling, possibly affecting RAIN expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, part of the MAPK pathway, which can influence RAS signaling pathways and potentially RAIN expression. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, affecting the RAS pathway and potentially influencing RAIN expression. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 is a Gsα subunit inhibitor, which can affect cAMP levels and potentially influence signaling pathways involving RAIN. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
GTPγS is a non-hydrolyzable GTP analogue that can activate GTPases, potentially modulating RAS family proteins including RAIN. | ||||||