RAG-1 Activators
The chemical class of RAG-1 activators encompasses a diverse range of compounds that exert their influence on RAG-1 expression and activity through intricate cellular pathways. These compounds, while not directly targeting RAG-1, play pivotal roles in modulating signaling cascades crucial for the initiation of V(D)J recombination during lymphocyte development. One prominent group within the RAG-1 activators includes inhibitors of protein phosphatases, such as Calyculin A, which indirectly enhance RAG-1 activity by sustaining phosphorylation events. This sustained phosphorylation promotes the stability and function of key proteins involved in V(D)J recombination. Additionally, tyrosine kinase inhibitors like Dasatinib disrupt B cell receptor (BCR) signaling, indirectly influencing RAG-1 activation during early B cell development. Retinoic acid derivatives, including 9-cis-Retinoic acid and ATRA, act as ligands for retinoic acid receptors (RARs), indirectly activating RAG-1 by modulating gene expression. These compounds play a crucial role in orchestrating the transcriptional machinery necessary for efficient V(D)J recombination. Similarly, inhibitors of PI3K, such as Wortmannin, and mTOR inhibitors like Rapamycin, indirectly activate RAG-1 by disrupting signaling pathways crucial for lymphocyte development.
Broad-spectrum protein kinase inhibitors, exemplified by Ro 31-8220, and selective inhibitors targeting specific kinases, like PD98059 inhibiting MEK1/2, influence RAG-1 indirectly by altering signaling events crucial for immune cell maturation. The inhibition of these kinases shifts the cellular milieu, creating an environment conducive to efficient V(D)J recombination. Compounds like Leflunomide, Bisindolylmaleimide I, SP600125, and SB216763 contribute to RAG-1 activation by disrupting various cellular pathways involved in lymphocyte development. Leflunomide, targeting dihydroorotate dehydrogenase (DHODH), indirectly influences RAG-1 by altering the cellular environment necessary for efficient V(D)J recombination. In conclusion, the chemical class of RAG-1 activators showcases a repertoire of compounds that indirectly enhance RAG-1 expression and activity by modulating specific cellular pathways crucial for lymphocyte development. Understanding the nuanced interactions of these compounds with cellular signaling networks provides valuable insights into potential strategies for manipulating RAG-1 during V(D)J recombination, contributing to the broader landscape of immune system research.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases, particularly PP1 and PP2A. By inhibiting these phosphatases, Calyculin A can indirectly activate RAG-1 through sustained phosphorylation events, enhancing the stability and activity of key proteins involved in RAG-1 function. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
9-cis-Retinoic acid is an isomer of retinoic acid and acts as a ligand for retinoic acid receptors (RARs). It indirectly activates RAG-1 by modulating gene expression through RARs, which can influence the transcriptional machinery involved in RAG-1 regulation during immune cell development. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a potent PI3K inhibitor, indirectly activates RAG-1 by disrupting the PI3K/Akt signaling pathway. Through inhibition of PI3K, Wortmannin alters downstream signaling events, impacting cellular processes that regulate RAG-1 expression and function during lymphocyte development. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro 31-8220 is a broad-spectrum protein kinase inhibitor that indirectly activates RAG-1. By inhibiting various protein kinases, Ro 31-8220 disrupts signaling pathways involved in immune cell development, influencing the transcriptional regulation of RAG-1 and enhancing its activity during V(D)J recombination. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $83.00 | 5 | |
Leflunomide is an inhibitor of dihydroorotate dehydrogenase (DHODH) and indirectly activates RAG-1. By targeting DHODH, Leflunomide disrupts de novo pyrimidine synthesis, influencing cellular processes crucial for lymphocyte development. This indirect activation occurs through modulation of the intracellular environment necessary for RAG-1 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK1/2, affecting the MAPK/ERK signaling pathway. It indirectly influences RAG-1 by disrupting MAPK/ERK-mediated events crucial for lymphocyte development. PD98059's impact on this pathway alters the cellular milieu, indirectly activating RAG-1 and promoting efficient V(D)J recombination during immune cell maturation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA, a natural derivative of vitamin A, acts as a ligand for retinoic acid receptors (RARs). It indirectly activates RAG-1 by modulating gene expression through RARs, thereby influencing the transcriptional machinery involved in RAG-1 regulation during immune cell development. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a potent inhibitor of protein kinase C (PKC). It indirectly influences RAG-1 by disrupting PKC-mediated signaling pathways, which are intricately linked to early B cell development. The inhibition of PKC alters the cellular environment, indirectly activating RAG-1 and facilitating efficient V(D)J recombination. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK (c-Jun N-terminal kinase) inhibitor that indirectly activates RAG-1. By inhibiting JNK, SP600125 disrupts signaling pathways involved in immune cell development, influencing the transcriptional regulation of RAG-1 and enhancing its activity during V(D)J recombination. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a GSK-3β inhibitor that indirectly activates RAG-1. By inhibiting GSK-3β, SB216763 influences Wnt signaling, which is crucial for lymphocyte development. This compound indirectly activates RAG-1 by modulating the Wnt pathway, altering the cellular environment necessary for efficient V(D)J recombination during immune cell maturation. | ||||||