Rab11-FIP1 Activators
Rab11-FIP1, or Rab11 Family Interacting Protein 1, is a critical regulator in the endosomal recycling system, a key component in maintaining cellular homeostasis and facilitating the precise distribution of proteins and lipids across the cell. It specifically interacts with Rab11, a member of the small GTPase family, to orchestrate the recycling of endosomes, thereby playing a vital role in processes such as cell signaling, membrane trafficking, and the preservation of cellular morphology. Rab11-FIP1's ability to bind to GTP-bound Rab11 is fundamental for its function, enabling the recruitment of recycling endosomes to specific sites within the cell, such as the plasma membrane or trans-Golgi network. This interaction is crucial for the targeted delivery of cargo, including transmembrane receptors, which must be precisely regulated to respond to extracellular signals and maintain cellular functions.
The activation of Rab11-FIP1 is intricately linked to its interaction with Rab11 and is modulated through various cellular mechanisms that ensure its functionality in response to cellular demands. Activation can be induced by the binding of Rab11 in its GTP-bound form, which signifies its 'active' state. This interaction is not static; it is regulated by the guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP on Rab11, thus promoting the active Rab11-FIP1 complex formation. Additionally, the spatial and temporal regulation of Rab11-FIP1 activity is influenced by post-translational modifications, such as phosphorylation, which can enhance its affinity for Rab11 or alter its conformation, enabling the efficient recruitment of cargo proteins. Other cellular factors, including scaffolding proteins and lipids within the membrane, can also modulate the activation state of Rab11-FIP1, facilitating its proper localization and function within the endosomal recycling pathway. Through these mechanisms, the cell can dynamically regulate Rab11-FIP1 activity, ensuring that endosomal recycling processes are precisely tuned to the cellular environment and metabolic status, thereby maintaining cellular integrity and responsiveness to external and internal cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A disrupts actin cytoskeleton dynamics, which can indirectly impact membrane trafficking processes by altering vesicle transport pathways. This disruption can lead to changes in Rab11-FIP1 activity as it participates in vesicular recycling. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits the function of small GTPases like Arf1, which are involved in vesicular transport and Golgi organization. By interfering with these processes, it indirectly influences the regulation of Rab11-FIP1 and its participation in vesicle recycling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor that affects membrane trafficking by altering lipid signaling pathways. Disruption of these pathways can indirectly modulate Rab11-FIP1 function in vesicle recycling. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, a protein involved in endocytosis and vesicle scission. By interfering with endocytic processes, Dynasore indirectly influences the dynamics of vesicle recycling, potentially affecting Rab11-FIP1 activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule dynamics, which are crucial for intracellular vesicle transport. The perturbation of microtubule-based trafficking pathways can indirectly impact Rab11-FIP1's role in vesicle recycling. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to affect lysosomal function and trafficking. Altered lysosomal dynamics can indirectly influence endosomal recycling pathways, potentially affecting Rab11-FIP1 activity in vesicle recycling. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose can interfere with glycolytic processes and energy metabolism. Changes in cellular energy availability may indirectly affect membrane trafficking pathways, including those involving Rab11-FIP1. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments, impacting cytoskeletal dynamics. This alteration in actin organization can indirectly influence vesicle trafficking and Rab11-FIP1-mediated recycling processes. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization, affecting the organization of the actin cytoskeleton. This indirectly influences vesicle transport pathways, potentially impacting Rab11-FIP1 function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin targets Hsp90, a molecular chaperone involved in protein folding and trafficking. By interfering with Hsp90 function, Geldanamycin can indirectly influence the proper folding and trafficking of proteins, potentially impacting Rab11-FIP1-associated vesicle recycling. | ||||||