Rab11-FIP1 Antibody (3A12H9D2): sc-517228
- Rab11-FIP1 Antibody (3A12H9D2) is a mouse monoclonal IgG1 κ Rab11-FIP1 antibody, cited in 2 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 130-271 of Rab11-FIP1 of human origin
- recommended for detection of Rab11-FIP1 of mouse, rat and human origin by WB, IP, IF, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab11-FIP1 Antibody (3A12H9D2). This work is in progress.
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Rab11-FIP1 Antibody (3A12H9D2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab11-FIP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab11-FIP1 antibody (3A12H9D2) is available as the non-conjugated format. Rab11-FIP1, also known as Rab-coupling protein (RCP), is a 1283 amino acid effector protein that plays a crucial role in the endosomal recycling process by interacting with Rab GTPases. This interaction is vital for controlling membrane trafficking along the phagocytic pathway and during phagocytosis, processes that are essential for cellular homeostasis and immune response. Rab11-FIP1 is primarily localized to the recycling endosome, cytoplasmic membrane, and phagosome membranes, and is expressed in five isoforms produced by alternative splicing, with isoform two being the most highly expressed in tissues such as the brain, lung, testis, small intestine, spleen, and heart. Notably, isoform two of Rab11-FIP1 forms homooligomers and interacts with several Rab GTPases, including Rab 4A, Rab 11A, Rab 11B, and Rab 25, highlighting its importance in the regulation of intracellular transport mechanisms.
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Rab11-FIP1 Antibody (3A12H9D2) References:
- Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. | Cullis, DN., et al. 2002. J Biol Chem. 277: 49158-66. PMID: 12364336
- The RCP-Rab11 complex regulates endocytic protein sorting. | Peden, AA., et al. 2004. Mol Biol Cell. 15: 3530-41. PMID: 15181150
- Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. | Lindsay, AJ. and McCaffrey, MW. 2004. FEBS Lett. 571: 86-92. PMID: 15280022
- Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. | Damiani, MT., et al. 2004. Traffic. 5: 785-97. PMID: 15355514
- Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner. | Marie, N., et al. 2005. Biochem J. 389: 223-31. PMID: 15769254
- The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. | Jin, M. and Goldenring, JR. 2006. Biochim Biophys Acta. 1759: 281-95. PMID: 16920206
- Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers. | Letessier, A., et al. 2006. BMC Cancer. 6: 245. PMID: 17040570
- Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. | Caswell, PT., et al. 2008. J Cell Biol. 183: 143-55. PMID: 18838556
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab11-FIP1 Antibody (3A12H9D2) | sc-517228 | 100 µg/ml | $322.00 |