Rab 3D Activators
Rab 3D Activators encompass a diverse spectrum of chemical entities that either directly bind and activate Rab 3D or modulate various cellular pathways to enhance its functional role in vesicle trafficking. GTP, the quintessential activator, directly engages Rab 3D in a GTP-bound active state, crucial for its role in vesicle movement and membrane fusion. The analog Guanosine-5'-O-(3-thiotriphosphate) (GTPγS) ensures a persistent active state of Rab 3D by resisting hydrolysis, thus facilitating extended periods of vesicular transport. Phosphatidylinositol 3-phosphate, a phospholipid product of PI3K, recruits downstream effector proteins that associate with Rab 3D, amplifying its vesicle trafficking capabilities. Forskolin, by raising intracellular cAMP levels, potentially activates Rab 3D via PKA-mediated phosphorylation of associated proteins, indirectly influencing vesicular dynamics.
The actin cytoskeleton and microtubule disruptors, Cytochalasin D and Nocodazole, respectively, trigger compensatory mechanisms that likely result in enhanced Rab 3D activity to maintain intracellular trafficking under cytoskeletal stress. Brefeldin A and Monensin, by interfering with Golgi dynamics and ionic gradients, may indirectly necessitate elevated Rab 3D activity to rebalance vesicle flow. The ionophore Neomycin perturbs phosphoinositide function, potentially catalyzing a homeostatic increase in Rab 3D's trafficking role. Lithium ions, by modulating inositol signaling, could evoke a similar compensatory response. ML141, as a Cdc42 inhibitor, may inadvertently boost Rab 3D function as the cell adjusts its vesicular traffic management. Lastly, Paclitaxel's stabilization of microtubules could favor Rab 3D-mediated vesicle transport along these structures, thereby enhancing its activity in cellular logistics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
A non-hydrolyzable analog of GTP, which can bind to Rab 3D and maintain it in an active state, thus enhancing its role in vesicular trafficking without the need for GTP hydrolysis. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus and indirectly activates Rab 3D by blocking the activation of ARF proteins, which then allows Rab 3D to regulate alternative pathways for vesicle trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts intracellular ionic gradients and lysosomal function, leading to a compensatory response that often includes the activation of Rab proteins, including Rab 3D, to restore cellular homeostasis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By elevating cAMP, Forskolin can indirectly activate Rab 3D through PKA-dependent phosphorylation of downstream effectors that interact with Rab 3D, thus promoting vesicle trafficking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, and cells compensate by activating Rab proteins to maintain vesicular traffic in the absence of normal microtubule tracks, potentially enhancing Rab 3D activity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
As an actin polymerization inhibitor, Cytochalasin D can lead to reorganization of the cytoskeleton and subsequent compensatory activation of Rab 3D to maintain vesicle transport processes. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $26.00 $34.00 | 20 | |
Neomycin binds to phosphoinositides and can disrupt their function, which may lead to the activation of Rab 3D as it seeks to restore vesicular trafficking homeostasis. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can affect several signaling pathways, including the phosphoinositide pathway, which has downstream effects on vesicular trafficking, potentially enhancing the activity of Rab 3D in this capacity. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a Cdc42 inhibitor and by inhibiting Cdc42, it may lead to compensatory activation of Rab 3D to maintain the regulation of vesicle trafficking and membrane dynamics within the cell. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol (Paclitaxel) stabilizes microtubules and can potentially enhance the activity of Rab 3D by promoting microtubule-dependent vesicle transport, which is a process Rab 3D is known to be involved in. | ||||||