Rab 18 Activators
The class of Rab18 Activators consists of compounds that can indirectly influence the activity of Rab18, a Rab family GTPase involved in membrane trafficking. These compounds act primarily by affecting the biological processes and signaling pathways with which Rab18 is associated.
The Rab18 Activators class includes purine nucleotides like GTP and GDP, which influence Rab18's switch between inactive and active states. Cellular disruption agents like Brefeldin A, Nocodazole, and Cytochalasin D can activate Rab18 by disrupting the Golgi apparatus and cytoskeleton, respectively, which Rab18 is known to localize and influence. The class also includes inhibitors such as PI3K inhibitors, Akt inhibitors, Rapamycin, U18666A, Wortmannin, PD98059, and GF109203X, which can influence Rab18 activity by altering signaling pathways and cellular processes that Rab18 is associated with.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-diphosphate sodium salt hydrate (GDP) | 146-91-8 non-salt | sc-507402 | 10 mg | $645.00 | ||
Guanosine diphosphate (GDP) is a purine nucleotide that is bound by inactive Rab18. Its removal can allow for GTP binding and Rab18 activation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A can indirectly activate Rab18 by disrupting the Golgi apparatus, where Rab18 is known to localize. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule-disrupting agent that can indirectly activate Rab18 by altering cytoskeleton dynamics, which Rab18 is known to influence. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D is a cell-permeable mycotoxin that can indirectly activate Rab18 by disrupting actin filaments, impacting membrane trafficking processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor (LY294002) can indirectly influence Rab18 activity by modulating PI3K signaling, which is known to affect Rab18's localization and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an immunosuppressant that can indirectly activate Rab18 by inhibiting mTOR, a central regulator of cell growth and survival. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A is a cholesterol transport inhibitor that can indirectly influence Rab18 activity by disrupting lipid distribution, which Rab18 is known to regulate. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor that can indirectly influence Rab18 activity by inhibiting PI3K, which may influence Rab18-dependent processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that can indirectly influence Rab18 activity by modulating MAPK signaling, which Rab18 may interact with. | ||||||