PXR Activators
Items 11 to 18 of 18 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hyperforin dicyclohexylammonium salt | 238074-03-8 | sc-202178 sc-202178A | 500 µg 1 mg | $137.00 $180.00 | 1 | |
Hyperforin dicyclohexylammonium salt acts as a potent modulator of the pregnane X receptor (PXR), exhibiting unique binding dynamics that promote receptor dimerization. Its distinctive hydrophobic regions enhance molecular interactions, leading to altered receptor conformations. The compound's specific steric effects influence the rate of ligand binding and dissociation, thereby impacting downstream signaling pathways and gene expression related to metabolic processes. | ||||||
2,2-Bis(4-hydroxyphenyl)butane | 77-40-7 | sc-352249 sc-352249A | 5 g 25 g | $145.00 $351.00 | 3 | |
2,2-Bis(4-hydroxyphenyl)butane functions as a selective modulator of the pregnane X receptor (PXR), characterized by its ability to stabilize receptor-ligand complexes through hydrogen bonding and hydrophobic interactions. This compound exhibits unique conformational flexibility, allowing it to adapt to various binding sites on the receptor. Its kinetic profile reveals a distinct rate of activation, influencing transcriptional regulation of genes involved in xenobiotic metabolism and homeostasis. | ||||||
Tris(2-butoxyethyl) phosphate | 78-51-3 | sc-237373 | 100 g | $51.00 | 10 | |
Tris(2-butoxyethyl) phosphate acts as a potent modulator of the pregnane X receptor (PXR), showcasing its ability to engage in specific electrostatic interactions that enhance receptor activation. Its unique branched structure promotes solubility and facilitates rapid diffusion across cellular membranes. The compound's distinct steric configuration allows for effective binding to PXR, influencing downstream signaling pathways related to detoxification processes and lipid metabolism. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
GW 9662 is a selective antagonist of the peroxisome proliferator-activated receptor gamma (PPARγ), exhibiting unique binding characteristics that disrupt receptor dimerization. Its hydrophobic regions enhance affinity for lipid bilayers, promoting cellular uptake. The compound's specific conformational changes upon binding alter the receptor's transcriptional activity, impacting gene expression related to metabolic regulation. Additionally, GW 9662's kinetic profile suggests a reversible interaction, allowing for nuanced modulation of PPARγ activity. | ||||||
5-Pregnen-3β-ol-20-one-16α-carbonitrile | 1434-54-4 | sc-227010 | 50 mg | $68.00 | 3 | |
Potent rodent-specific PXR agonist. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Antifungal that has been shown to activate PXR in certain studies. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Has been shown to activate PXR and induce its target genes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Known to influence PXR activity, potentially leading to alterations in PXR expression. | ||||||