PXR Activators
Items 1 to 10 of 18 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Known agonist of PXR; induces its activation and potentially its expression. | ||||||
Hyperforin | 11079-53-1 | sc-507549 | 250 µg | $420.00 | ||
Acts as a potent activator of PXR, leading to increased expression of target genes. | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $109.00 | 3 | |
DHEA functions as a potent ligand for the pregnane X receptor (PXR), influencing gene expression related to xenobiotic metabolism. Its structural conformation allows for effective binding, triggering distinct signaling cascades. The compound exhibits unique hydrophobic interactions, enhancing its stability in lipid environments. Furthermore, DHEA's metabolic pathways involve intricate enzymatic conversions, contributing to its diverse biological effects and regulatory mechanisms within cellular systems. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $85.00 $145.00 $340.00 $1100.00 | ||
Pregnenolone acts as a significant ligand for the pregnane X receptor (PXR), modulating transcriptional activity linked to various metabolic processes. Its unique steric configuration facilitates specific interactions with PXR, leading to the activation of downstream signaling pathways. The compound's lipophilic nature promotes its integration into cellular membranes, influencing membrane fluidity and receptor accessibility. Additionally, pregnenolone undergoes complex metabolic transformations, impacting its bioavailability and functional outcomes in cellular environments. | ||||||
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
Has been shown to activate PXR and subsequently influence the expression of PXR target genes. | ||||||
Rifaximin | 80621-81-4 | sc-205841B sc-205841C sc-205841 sc-205841A sc-205841D | 100 mg 250 mg 500 mg 1 g 5 g | $27.00 $41.00 $77.00 $103.00 $398.00 | 2 | |
Rifaximin serves as a notable ligand for the pregnane X receptor (PXR), engaging in selective binding that influences gene expression related to xenobiotic metabolism. Its unique structural features enable it to stabilize the PXR conformation, enhancing receptor activation. The compound's hydrophobic characteristics facilitate its partitioning into lipid bilayers, affecting cellular uptake and distribution. Furthermore, rifaximin's metabolic pathways involve intricate enzymatic interactions, shaping its pharmacokinetic profile and biological effects. | ||||||
Meclizine Dihydrochloride | 1104-22-9 | sc-211779A sc-211779 | 5 g 10 g | $66.00 $138.00 | 3 | |
Meclizine Dihydrochloride acts as a potent modulator of the pregnane X receptor (PXR), exhibiting a distinct affinity that alters transcriptional activity linked to metabolic processes. Its unique molecular structure promotes specific interactions with PXR, leading to conformational changes that enhance receptor signaling. The compound's lipophilic nature aids in its integration into cellular membranes, influencing its bioavailability and interaction with various metabolic enzymes, thereby impacting its kinetic behavior in biological systems. | ||||||
TCPOBOP | 76150-91-9 | sc-203291 | 25 mg | $209.00 | 4 | |
TCPOBOP serves as a selective agonist for the pregnane X receptor (PXR), characterized by its ability to induce significant conformational shifts in the receptor's structure. This compound engages in unique hydrogen bonding and hydrophobic interactions, facilitating enhanced receptor activation. Its distinct electronic properties influence the kinetics of ligand-receptor binding, promoting efficient transcriptional regulation of genes involved in xenobiotic metabolism and homeostasis. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $32.00 $70.00 | 5 | |
Another antiepileptic agent that can activate PXR. | ||||||
SR 12813 | 126411-39-0 | sc-204296 sc-204296A | 10 mg 50 mg | $89.00 $338.00 | ||
Synthetic compound known to be a potent PXR agonist. | ||||||