PSG3 Activators
PSG3 engage various signaling pathways to influence its functional activity within the placental environment during pregnancy. Estradiol, by binding to estrogen receptors, initiates gene expression regulation that encourages cell growth and differentiation, which can lead to the activation of PSG3 in placental tissues. Similarly, the interaction of insulin with its receptors activates the PI3K/Akt signaling pathway, influencing metabolism, growth, and survival, and this activation is conducive to the functional state of PSG3 in relation to placental development. The epidermal growth factor (EGF) contributes to this process by binding to its receptor, which stimulates the MAPK/ERK pathway responsible for cellular proliferation and survival, thereby supporting placental growth and the functional state of PSG3.
Progesterone, acting through its receptors, modulates reproductive processes that are essential for maintaining the uterine lining, promoting an environment favorable for placental development that can lead to PSG3 activation. Human Chorionic Gonadotropin (hCG) extends this support by maintaining the corpus luteum and progesterone production, further influencing placental development and PSG3 activity. Moreover, the role of leptin in activating the JAK/STAT pathway is crucial for regulating immune responses and inflammation, which can modulate maternal immune tolerance and influence the functional state of PSG3 in the placenta. Interferon-gamma (IFN-γ) also activates the JAK/STAT pathway, playing a role in the immune system modulation during pregnancy that can facilitate the functional state of PSG3. The importance of folic acid in DNA synthesis and cell division underscores its contribution to a healthy placental environment and the functional state of PSG3. Additionally, nitric oxide donors like Sodium Nitroprusside can enhance blood flow to the placenta, optimizing nutrient and oxygen delivery that can support PSG3 activity. Vitamin D3 and IGF-1, through their respective receptors, activate pathways that regulate cell proliferation and differentiation, contributing to placental development and the functional state of PSG3. Lastly, glucocorticoids like cortisol, by binding to their receptors, regulate gene expression and modulate the energy metabolism that is involved in fetal organ maturation, which can support the functional activity of PSG3 in fetal development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol binds to estrogen receptors which are involved in the regulation of gene expressions. When estrogen receptors are activated, they can initiate a cascade of downstream signals that promote cell growth and differentiation, and since PSG3 is a pregnancy-specific glycoprotein, the activation of estrogen receptors during pregnancy could lead to the functional activation of PSG3 in placental tissues. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin triggers the PI3K/Akt signaling pathway, which is known to regulate a wide variety of cellular processes including metabolism, growth, and survival. Since PSG3 expression is related to pregnancy, the activation of this pathway can lead to changes in nutrient transport and angiogenesis in placental development, potentially leading to the functional activation of PSG3. | ||||||
Leptin (mouse), (recombinant) | 181030-10-4 | sc-471278 | 1 mg | $400.00 | 1 | |
Leptin interacts with its receptors to activate the JAK/STAT pathway, a pathway that plays a significant role in the regulation of immune responses and inflammation. During pregnancy, the functional activation of this pathway could contribute to the modulation of maternal immune tolerance and placental development, where PSG3 may be functionally activated. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone acts through progesterone receptors which modulate a range of reproductive processes. In the context of pregnancy, progesterone is crucial for maintaining the uterine lining and could contribute to the functional activation of PSG3 in the placenta by promoting a supportive environment for placental development. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic Acid is crucial for DNA synthesis and repair. Its role in cell division and growth is particularly important during pregnancy, where it can contribute to placental development and function. This could lead to the functional activation of PSG3 by promoting a healthy environment for trophoblast growth and differentiation. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Sodium Nitroprusside releases nitric oxide which activates the cGMP pathway, leading to vasodilation and increased blood flow. In the context of pregnancy, improved blood flow can enhance placental function and potentially contribute to the functional activation of PSG3 by optimizing nutrient and oxygen delivery to the developing fetus. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 through its receptor can activate several signaling pathways that regulate gene expression, cell proliferation, and differentiation. During pregnancy, vitamin D3 is important for the immune system and may play a role in placental development, potentially leading to the functional activation of PSG3 in placental tissues. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Cortisol binds to glucocorticoid receptors, which can regulate gene expression and modulate immune responses. In pregnancy, cortisol is involved in the maturation of fetal organs and the regulation of energy metabolism, which can contribute to the functional activation of PSG3 in the preparation of the fetus for postnatal life. | ||||||