Leptin (mouse), (recombinant) (CAS 181030-10-4)
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Alternate Names:
OB gene product
Application:
Leptin (mouse), (recombinant) is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger
CAS Number:
181030-10-4
Purity:
≥95%
Molecular Weight:
~16000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Leptin (mouse), (recombinant), known as the satiety hormone, is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin (mouse), (recombinant) is opposed by the actions of the hormone ghrelin, the hunger hormone. Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite in order to achieve energy homeostasis. In obesity, a decreased sensitivity to Leptin (mouse), (recombinant) occurs, resulting in an inability to detect satiety despite high energy stores.
Leptin (mouse), (recombinant) (CAS 181030-10-4) References
- Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways. | Tajmir, P., et al. 2004. Endocrinology. 145: 1550-5. PMID: 14715711
- Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. | Maccarrone, M., et al. 2005. Mol Hum Reprod. 11: 21-8. PMID: 15563449
- Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. | Otero, M., et al. 2005. Arthritis Res Ther. 7: R581-91. PMID: 15899045
- Role of leptin in modulation of Porphyromonas gingivalis lipopolysaccharide-induced up-regulation of endothelin-1 in salivary gland acinar cells. | Slomiany, BL. and Slomiany, A. 2005. IUBMB Life. 57: 591-5. PMID: 16118117
- Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis. | Gultekin, FA., et al. 2007. World J Gastroenterol. 13: 2932-8. PMID: 17589942
- Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C₂C₁₂ muscle and AML12 liver cell lines. | Moon, HS., et al. 2012. Diabetologia. 55: 215-25. PMID: 21997794
- Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice. | Binder, E., et al. 2014. Obesity (Silver Spring). 22: 713-20. PMID: 23894080
- Effect of Leptin on In Vitro Nuclear Maturation and Apoptosis of Buffalo (Bubalus bubalis) Oocyte. | Khaki1, A., et al. 2014. Int J Fertil Steril. 8: 43-50. PMID: 24696768
- Protective effect of leptin on induced apoptosis with trichostatin A on buffalo oocytes. | Shafiei Sheykhani, HR., et al. 2016. Vet Res Forum. 7: 99-104. PMID: 27482353
- Preoptic leptin signaling modulates energy balance independent of body temperature regulation. | Yu, S., et al. 2018. Elife. 7: PMID: 29761783
- Functional heterogeneity of POMC neurons relies on mTORC1 signaling. | Saucisse, N., et al. 2021. Cell Rep. 37: 109800. PMID: 34644574
Activator of:
ACAD-10, Lipocalin-11, PRSS44, and PSG3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Leptin (mouse), (recombinant), 1 mg | sc-471278 | 1 mg | $408.00 |