Psf2 Inhibitors
Psf2 inhibitors belong to a chemical class designed to modulate the activity of the Psf2 protein, which is an essential component of the GINS complex. The GINS complex is involved in DNA replication and plays a pivotal role in ensuring accurate and efficient DNA synthesis during cell division. Psf2, as part of the GINS complex, interacts with other proteins to stabilize the replication fork, unwinding DNA strands and facilitating the incorporation of nucleotides.
Inhibitors targeting Psf2 aim to interfere with its role in DNA replication by potentially disrupting its interactions within the GINS complex. By modulating Psf2, these inhibitors could impact the progression of DNA replication and ultimately influence cell division processes. Developing Psf2 inhibitors involves designing compounds that interact with the protein's binding sites or specific domains, potentially affecting its ability to function within the GINS complex. By inhibiting Psf2, researchers aim to gain insights into the intricate mechanisms of DNA replication and explore the broader implications of targeting this protein for cellular processes and genome integrity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
An anticancer drug that interferes with DNA replication by cross-linking DNA strands. | ||||||
Gemcitabine Hydrochloride | 122111-03-9 | sc-204763 sc-204763A | 25 mg 100 mg | $96.00 $289.00 | 13 | |
An anticancer drug that inhibits DNA synthesis by acting as a nucleoside analog. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
An anticancer drug that disrupts microtubule dynamics and inhibits cell division. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
A drug used in cancer chemotherapy and autoimmune diseases that inhibits dihydrofolate reductase, interfering with DNA replication. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
A PARP inhibitor studied in the research of certain cancers, particularly those with BRCA mutations, which disrupts DNA repair mechanisms. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
An anticancer drug that induces DNA strand breaks and inhibits DNA synthesis. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline anticancer drug that intercalates with DNA, preventing DNA replication and inducing DNA damage. | ||||||