Date published: 2025-12-8

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pS2 Inhibitors

The chemical class referred to as PS2 Inhibitors encompasses a diverse group of molecules and compounds that have been developed and studied for their potential to modulate the activity of Presenilin-2 (PS2), a protein closely associated with the processing of amyloid precursor protein (APP) and implicated in the pathogenesis of certain neurological conditions. PS2 Inhibitors are intricately designed to interact with PS2 or related pathways, with the intention of interfering with the molecular events that contribute to the cleavage and processing of APP. By targeting PS2, these inhibitors offer a means to investigate and manipulate the intricate mechanisms that underlie APP processing and the production of specific peptide fragments.

The study of PS2 Inhibitors contributes to advancing our understanding of cellular processes and molecular interactions, shedding light on the complexities involved in protein processing and its potential implications for neurological health. Ongoing research endeavors continue to unravel the mechanisms of action and broader implications associated with PS2 Inhibitors, thereby enhancing our insights into the fundamental principles that govern protein metabolism and contribute to our understanding of neurodegenerative disorders.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

DAPT

208255-80-5sc-201315
sc-201315A
sc-201315B
sc-201315C
5 mg
25 mg
100 mg
1 g
$99.00
$335.00
$836.00
$2099.00
47
(3)

A γ-secretase inhibitor that can potentially affect PS2-mediated cleavage of APP.

Flurbiprofen

5104-49-4sc-202158
sc-202158A
100 mg
1 g
$69.00
$104.00
(1)

Also known as R-flurbiprofen, tarenflurbil is a derivative of flurbiprofen that has been studied for its potential to modulate PS2 and amyloid beta production.

L-685,458

292632-98-5sc-204042
sc-204042A
1 mg
5 mg
$337.00
$1000.00
4
(1)

A γ-secretase inhibitor that can potentially influence PS2-mediated cleavage of APP.

Semagacestat

425386-60-3sc-364614
sc-364614A
10 mg
50 mg
$350.00
$1200.00
1
(0)

An investigational γ-secretase inhibitor that has been studied in relation to PS2 activity and amyloid beta production.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

A compound found in turmeric, curcumin has been investigated for its potential to modulate PS2 and amyloid beta production.