PRPF31 Activators
Pre-mRNA processing factor 31, also known as PRPF31, is a protein that plays a crucial role in the splicing of pre-messenger RNA (pre-mRNA) in eukaryotic cells. Pre-mRNA splicing is a fundamental process in gene expression, where non-coding introns are removed from the pre-mRNA, and the remaining exons are ligated together to form mature mRNA, which can then be translated into proteins. PRPF31 is one of the core components of the spliceosome, a large ribonucleoprotein complex responsible for splicing pre-mRNA.
PRPF31 is specifically associated with the minor spliceosome, which is one of the two major types of spliceosomes in eukaryotic cells, alongside the major spliceosome. The minor spliceosome is responsible for removing rare and non-canonical introns that have distinct consensus sequences compared to those recognized by the major spliceosome. PRPF31 is an essential component of the minor spliceosome and plays a crucial role in its assembly and catalytic function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor with a broad specificity that could indirectly activate PRPF31 by modulating kinase-mediated signaling pathways involved in splicing regulation. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
A kinase inhibitor that might activate PRPF31 by regulating kinase-driven processes associated with spliceosome function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor with epigenetic-modifying properties that could indirectly activate PRPF31 by influencing the acetylation state of splicing-associated histones. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor known to impact gene expression, potentially activating PRPF31 by altering the acetylation patterns of spliceosome-related proteins. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
An inhibitor of protein synthesis that may indirectly activate PRPF31 by regulating the levels of key spliceosome components. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
A potent RNA polymerase II inhibitor, potentially affecting PRPF31 activation by disrupting transcription and pre-mRNA production. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor with immunosuppressive properties that might indirectly impact PRPF31 activation by modulating mTOR-mediated signaling pathways linked to splicing regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that could indirectly activate PRPF31 by altering DNA methylation patterns related to gene expression and splicing factors. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
An inhibitor of histone methyltransferases, potentially impacting PRPF31 activation by influencing histone methylation patterns linked to splicing regulation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that might indirectly affect PRPF31 activation by regulating protein degradation pathways connected to the spliceosome. | ||||||