PROX2 Activators
Chemical activators of PROX2 can engage the protein through several distinct biochemical pathways to enable its regulatory functions. Zinc ions are capable of binding to specific domains within PROX2, inducing a structural change that is favorable for DNA interaction and activation. Magnesium ions contribute to the structural integrity of the protein, which is crucial for its DNA-binding capacity. Calcium ions facilitate the interaction of PROX2 with other cofactors or directly with DNA, which is necessary for its activation as a transcription factor.
Certain chemicals serve to modify chromatin structure, thereby allowing PROX2 greater access to DNA. These include agents that inhibit histone deacetylases, leading to a more relaxed chromatin conformation and enhanced binding potential for PROX2. Other compounds can induce hypomethylation of DNA, augmenting the binding of PROX2 to its target sequences and therefore its activation. Some molecules can influence cellular differentiation pathways that include the activation of PROX2, by altering the expression of genes targeted by the protein. Moreover, other agents can increase intracellular levels of secondary messengers or directly activate kinases, leading to phosphorylation events that facilitate the activation of PROX2. Inhibition of certain kinases can also result in the stabilization and activation of PROX2 by preventing its degradation. Interactions with hormone receptors that engage with PROX2 may also modulate its activity and promote its role in gene regulation. Each chemical pathway contributes to the proper function of PROX2 by ensuring its active conformation and facilitating its interaction with DNA, enabling PROX2 to effectively regulate gene expression within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can activate prospero homeobox 2 by binding to the metal binding domain within the protein, which can induce a conformational change leading to its activation. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions can interact with prospero homeobox 2, facilitating its interaction with other cofactors or target DNA sequences, resulting in the activation of its transcriptional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate can act as a histone deacetylase inhibitor, leading to a relaxed chromatin structure around the DNA-binding sites that prospero homeobox 2 may target, thereby enhancing its binding and activation potential. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can incorporate into DNA and inhibit DNA methyltransferases, resulting in hypomethylation and potentially augmenting the binding of prospero homeobox 2 to its target DNA sequences, thus activating the protein. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, by inhibiting histone deacetylases, can increase acetylation of histones, which could lead to an accessible chromatin state for prospero homeobox 2 to bind and activate transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence cellular differentiation pathways that may include the activation of prospero homeobox 2 as part of the cascade, by altering the transcription of genes that the protein targets. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can lead to the phosphorylation of proteins that are part of the signaling pathways involving prospero homeobox 2, thereby facilitating its activation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit glycogen synthase kinase-3 (GSK-3), which may lead to the stabilization and activation of transcription factors including prospero homeobox 2 by preventing their degradation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 through its active metabolite, calcitriol, can engage with vitamin D receptors (VDRs), which can interact with prospero homeobox 2, possibly facilitating its activation and function in gene regulation. | ||||||