Prdx6-rs2 Inhibitors
Prdx6-rs2 inhibitors refer to a class of chemical compounds that specifically target and inhibit the redox-active site 2 (rs2) of the enzyme Peroxiredoxin 6 (Prdx6). Prdx6 is a member of the peroxiredoxin family of enzymes, which play a pivotal role in cellular redox regulation by reducing peroxides, primarily hydrogen peroxide, organic hydroperoxides, and phospholipid hydroperoxides. What distinguishes Prdx6 from other members of its family is its bifunctional enzymatic nature-it has both peroxidase and phospholipase A2 activities. The rs2 site is crucial for the catalytic cycle that facilitates its peroxidase function. Inhibitors of Prdx6-rs2 aim to modulate the enzymatic activity of this protein by specifically targeting this redox-active region. This selective inhibition can affect the redox balance within cells, impacting the downstream pathways associated with reactive oxygen species (ROS) management and lipid metabolism.
Structurally, Prdx6-rs2 inhibitors are typically designed to interfere with the conserved cysteine residue at the active site of Prdx6. This cysteine residue, often referred to as the peroxidatic cysteine, undergoes oxidation during the peroxidase cycle, leading to the reduction of peroxides. The inhibitors, through a variety of chemical interactions, prevent the oxidation of this cysteine, thus halting the enzyme's ability to detoxify peroxides. These inhibitors are often characterized by their high specificity for Prdx6, as other peroxiredoxins may possess slightly different active site configurations. Research into Prdx6-rs2 inhibitors involves the exploration of how they influence oxidative stress, cellular signaling pathways, and membrane dynamics, providing valuable insights into the biochemical mechanisms underlying redox biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen acts as a peroxiredoxin mimic and can directly inhibit peroxiredoxin activity, potentially leading to decreased expression of PRDX6 through negative feedback mechanisms. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $72.00 $104.00 | ||
Mercaptopurine, an inhibitor of thiopurine methyltransferase, can lead to increased levels of reactive oxygen species (ROS), potentially impacting the expression of PRDX6, which responds to oxidative stress. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin has been shown to induce oxidative stress and alter redox balance in cells. This disturbance in redox homeostasis could potentially impact the expression of PRDX6, a key regulator of cellular redox balance. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $151.00 $136.00 $317.00 $405.00 $944.00 $1837.00 | 24 | |
Diphenyleneiodonium is a known inhibitor of NADPH oxidase, which is a major source of cellular reactive oxygen species (ROS). Inhibition of NADPH oxidase by diphenyleneiodonium may impact PRDX6 expression due to altered ROS levels. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine has been reported to induce cellular oxidative stress. This induction of oxidative stress may potentially modulate PRDX6 expression, as PRDX6 is involved in mitigating oxidative damage. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A has been shown to induce oxidative stress and alter redox balance within cells. This disturbance in redox homeostasis could potentially impact the expression of PRDX6, a key regulator of cellular redox balance. | ||||||
Alda 1 | 349438-38-6 | sc-479867 | 50 mg | $300.00 | ||
NSC 95397 is a known inhibitor of NADPH oxidase, a major source of cellular reactive oxygen species (ROS). Inhibition of NADPH oxidase by NSC 95397 may impact PRDX6 expression due to altered ROS levels. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein has been reported to exhibit antioxidant properties and can modulate cellular redox balance. This modulation of redox balance could potentially impact the expression of PRDX6, a key regulator of cellular redox homeostasis. | ||||||
A77 1726 | 163451-81-8 | sc-207235 | 10 mg | $80.00 | 14 | |
Teriflunomide, an inhibitor of dihydroorotate dehydrogenase, can lead to increased levels of reactive oxygen species (ROS), potentially impacting the expression of PRDX6, which responds to oxidative stress. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $75.00 $221.00 | 6 | |
Carnosic acid has been reported to exhibit antioxidant properties and can modulate cellular redox balance. This modulation of redox balance could potentially impact the expression of PRDX6, a key regulator of cellular redox homeostasis. | ||||||