Molecular structure of Baicalein, CAS Number: 491-67-8
Baicalein (CAS 491-67-8)
See product citations (12)
Alternate Names:
5,6,7-Trihydroxyflavone
Application:
Baicalein is an inhibitor of Ca2+ uptake, 5-LO, and 12-LO
CAS Number:
491-67-8
Purity:
≥95%
Molecular Weight:
270.23
Molecular Formula:
C15H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Baicalein is a flavonoid originally found in the roots of Scutellaria baicalensis and several other plants, widely recognized for its biological activity in various research applications. The compound is of interest for its potent antioxidant properties, which make it a subject of study in oxidative stress-related research. Baicalein′s ability to scavenge reactive oxygen species and upregulate antioxidant defense mechanisms is particularly relevant in the investigation of cellular protection against oxidative damage. Additionally, the compound is noted for its role in modulating enzyme activity, including lipoxygenases and certain kinases, which are implicated in the signaling pathways of inflammation and tumor growth. This makes baicalein a useful tool in the study of mechanisms underlying inflammation and oncogenesis. Baicalein is also investigated for its potential effects on neuroprotective pathways and the modulation of neurotransmitter systems.
Baicalein (CAS 491-67-8) References
- Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. | Hsu, SL., et al. 2001. Eur J Pharmacol. 425: 165-71. PMID: 11513834
- Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes. | Shen, YC., et al. 2003. Eur J Pharmacol. 465: 171-81. PMID: 12650847
- Biological properties of baicalein in cardiovascular system. | Huang, Y., et al. 2005. Curr Drug Targets Cardiovasc Haematol Disord. 5: 177-84. PMID: 15853750
- Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. | Lee, HZ., et al. 2005. Anticancer Res. 25: 959-64. PMID: 15868934
- Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. | Deschamps, JD., et al. 2006. Bioorg Med Chem. 14: 4295-301. PMID: 16500106
- Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. | Lin, HY., et al. 2007. Biochim Biophys Acta. 1773: 1073-86. PMID: 17532486
- Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. | Tarragó, T., et al. 2008. Bioorg Med Chem. 16: 7516-24. PMID: 18650094
- Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies. | Chen, H., et al. 2014. Cancer Lett. 354: 5-11. PMID: 25128647
- Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine. | Kim, DH., et al. 2014. J Cancer Prev. 19: 153-60. PMID: 25337584
- The Fascinating Effects of Baicalein on Cancer: A Review. | Liu, H., et al. 2016. Int J Mol Sci. 17: PMID: 27735841
- Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors. | Gong, WY., et al. 2017. Eur J Med Chem. 126: 844-852. PMID: 27960146
- Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. | Kimura, Y., et al. 1987. Biochim Biophys Acta. 922: 278-86. PMID: 2825795
- Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. | Dinda, B., et al. 2017. Eur J Med Chem. 131: 68-80. PMID: 28288320
- Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma. | Bie, B., et al. 2017. Biomed Pharmacother. 93: 1285-1291. PMID: 28747003
- Selective inhibition of platelet lipoxygenase by baicalein. | Sekiya, K. and Okuda, H. 1982. Biochem Biophys Res Commun. 105: 1090-5. PMID: 6807310
Inhibitor of:
β-defensin 3B, β-defensin 41, β-Glucoronidase, β-synuclein, γ-casein, γN-crystallin, 12-LO, 15-LO, 2210016F16Rik, 4-HNE, 5-LO, 8-OHdG, Alox12e, ALOXE3, AQP4, BPV E2, Clusterin-L1, COL15A1, COL5A2, Collagen Type IV, Collagen Type IV-α2, connexin 23, connexin 36, connexin 39, CPVL, CRP, CYP2C9, Cyp4f14, EG574081, Epidermis-type 12-LO, ferritin, fibrillin-2, FLAP, FLTR3, GAGE10, group V PLA2, Heme Oxygenase 1, HFE, HIV-1 Gag, HPV16 E1, HPV16 L2, HSP 105, HSP 47, HSV-1 UL42, HuC, Iba1, IL-33, Influenza B NA, Ivl, KLK11, lactoferrin, LOX, LOXL1, LRP, LRRC3B, MAdCAM, MBP, MCPIP, Measles NP, Metaxin 1, Mox1, NEI, NGAL, Olfr456, Olfr784, Olfr790, Olfr970, p47-phox, PKC, PLSCR2, Prdx6-rs2, PREP, Properdin, Protein tyrosine phosphatase receptor (PTPR), Psg29, PTPψ, RAO, RAP1, Reg ll, resistin-like γ, RFT1, RGD1304773, Rhox6, Rhox7, S-100A15, SA-1, Ser/Thr Protein Kinase, SR140, SULT2A2, SULT5A1, SV40 T Ag, Svs1, Svs2, Svs6, syncytin-A, Syndecan-2, T2R134, T2R17, T2R37, TAAR3, TAAR7A, TALK-2, TARDBP, TIAR, TLR12, TLR3, TMEM164, TNF-R2, tNOX, Tom1, TRAF7, Trav9d-1, Trk1, TWIK-2, TYW1B, UGT1A6B, UGT2A1, UGT2B37, UGT2B38, UGT2B5, V1RC2, V1RC21, V1RC25, V1rc7, V1RF4, V1RG11, vanin-3, Xlr4a, Xlr5a, Xlr5b, Ythdc1, YY1, and ZSCAN4F.Activator of:
α2ML1, β-defensin 10, ADF, Alox12e, BBS9, Bclp2, BLM, C030014O09Rik, C1r, C5, CALCA, Carbonyl reductase 3, casein kinase IIα′, CD163, Centrin-2, connexin 37, creatine kinase-M, cryptdin 22, cryptdin 24, cryptdin 25, cryptdin 3, Cyp2c69, CYP2J8, Cyp3a16, CYP4F3, Cypt2, dlg, DNAH2, DnaJA4, DnaJB3, DnaJC5B, Dnmt1, EG384589, EG434396, ENX-1, FBXW22, Fn14, GALR2, GROα, Helicobacter pylori HSP, Hep C NS5b, IL-1RAcP, Integrin β1, Jun D, K-cadherin, LAP3, LOC100039899, MBIP, MRS2L, OR10K1, OTOP1, PADI3, Per2, PIAS 1, Ribosomal Protein L30, SerpinA3j, SETX, Skp2 p45, SOCS-1, spectrin β V, SPOP, SULT2A4, TASK-3, TBC1D3B, TBC1D3C, TGFβ, TIMP-2, Tollip, TRIM30C, Trk B, USP49, Vitronectin, WDR40A, ZBTB6, ZNF434, ZNF484, and ZNF79.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Baicalein, 10 mg | sc-200494 | 10 mg | $32.00 | |||
Baicalein, 100 mg | sc-200494A | 100 mg | $42.00 | |||
Baicalein, 500 mg | sc-200494B | 500 mg | $162.00 | |||
Baicalein, 1 g | sc-200494C | 1 g | $292.00 |