PRAME like-7 Inhibitors
PRAME like-7 Inhibitors encompass a range of chemical compounds that target various signaling pathways and molecular functions, each with a unique mechanism of action that ultimately leads to the inhibition of PRAME like-7. Staurosporine, as a broad-spectrum kinase inhibitor, prevents phosphorylation processes essential for PRAME like-7's regulatory roles, thereby effectively silencing its activity. Meanwhile, Nutlin-3a upregulates p53, which serves as a transcription factor that can negatively regulate PRAME like-7 expression. Histone deacetylase inhibitors like Trichostatin A modulate chromatin structure, consequently affecting gene expression profiles, including that of PRAME like-7. Similarly, PI3K and mTOR pathways, targeted by LY294002 and Rapamycin respectively, intersect with cell growth and proliferation processes that could encompass the regulatory network of PRAME like-7, leading to its functional inhibition when these pathways are suppressed.
Continuing with this theme, MEK inhibitors such as PD98059 and U0126, RAF kinase inhibitor GW5074, and c-Raf selective inhibitor ZM336372 disrupt the MAPK/ERK pathway, a potential modulator of PRAME like-7. Inhibitors like SP600125 and SB203580, which target JNK and p38 MAPK respectively, can impair the signaling pathways that may be responsible for upregulating PRAME like-7. Bortezomib's proteasome inhibition could lead to the accumulation of regulatory proteins that inhibit PRAME like-7 indirectly, by modulating protein degradation pathways. Collectively, these inhibitors demonstrate a multipronged approach to silencing PRAME like-7.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent non-selective inhibitor of protein kinases which can inhibit PRAME like-7 by hindering phosphorylation events critical for its function. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $120.00 $215.00 | 2 | |
Nutlin-3a is a MDM2 antagonist which leads to p53 activation. p53 can regulate the expression of PRAME like-7, potentially leading to its decreased expression and inhibition. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. Altered acetylation levels can affect the chromatin structure and gene expression, including genes like PRAME like-7. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which can downregulate AKT signaling, a pathway that may intersect with PRAME like-7 regulatory mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in cell growth and proliferation, processes that could involve PRAME like-7. By inhibiting mTOR, PRAME like-7's associated functions can be downregulated. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor which can decrease ERK pathway activity, thereby potentially suppressing the expression or activity of PRAME like-7 if it is part of this signaling cascade. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a RAF kinase inhibitor. By inhibiting RAF, downstream signaling including the expression or activation of PRAME like-7 could be inhibited. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor, which can dampen the JNK signaling pathway. Inhibition of this pathway may negatively influence PRAME like-7 expression or activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor which could downregulate inflammatory signaling pathways that might upregulate PRAME like-7, leading to its functional inhibition. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that leads to accumulation of regulatory proteins that could inhibit PRAME like-7 indirectly by modulating degradation pathways. | ||||||