Date published: 2026-5-5

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PRAK Inhibitors

PRAK inhibitors constitute a chemical class of compounds that and reversibly target PRAK (p38-regulated/activated protein kinase), a member of the MAPK (mitogen-activated protein kinase) family. PRAK plays a critical role in cellular signaling pathways involved in stress responses, inflammation, apoptosis, and cell proliferation. Inhibiting PRAK activity is of interest in scientific research to understand its functions and roles in various cellular processes. The chemical structure of PRAK inhibitors allows them to interact with specific regions or binding sites on the kinase, thereby interfering with its catalytic activity and downstream signaling cascades.

Researchers utilize PRAK inhibitors in biochemical and cellular studies to investigate the physiological and pathological roles of PRAK in cellular signaling, without reference to drug applications. The design and development of these inhibitors rely on a comprehensive understanding of PRAK's structural features and its involvement in cellular responses to stress, inflammation, and cellular growth, providing valuable tools for advancing research in the field of cellular signaling and kinase regulation.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rottlerin

82-08-6sc-3550
sc-3550B
sc-3550A
sc-3550C
sc-3550D
sc-3550E
10 mg
25 mg
50 mg
1 g
5 g
20 g
$84.00
$166.00
$302.00
$2091.00
$5212.00
$16657.00
51
(2)

Rottlerin (CAS 82-08-6) is a natural chemical compound derived from Mallotus philippinensis. It acts as an inhibitor of PRAK (p38-regulated/activated protein kinase), a member of the MAPK family. By targeting PRAK, Rottlerin modulates cellular signaling pathways involved in stress responses, apoptosis, and cell differentiation. Its specific interaction with PRAK makes it a valuable tool in research to investigate the roles of this kinase in various cellular processes.

CID 755673

521937-07-5sc-205246
10 mg
$203.00
1
(1)

CID 755673 (CAS 521937-07-5) is a chemical compound known for its inhibitory effects on PRAK (p38-regulated/activated protein kinase), a member of the MAPK family. By selectively targeting PRAK, CID 755673 interferes with cellular signaling pathways involved in stress responses, apoptosis, and cell differentiation. Its specific inhibition of PRAK makes it a valuable tool in scientific research to investigate the functions and roles of this kinase in various cellular processes.

MK-2 Inhibitor III

1186648-22-5sc-221948
5 mg
$400.00
3
(1)

MK-2 Inhibitor III (CAS 1186648-22-5) is a chemical compound that acts as an inhibitor of PRAK (p38-regulated/activated protein kinase). By selectively targeting PRAK, MK-2 Inhibitor III interferes with cellular signaling pathways involved in stress responses, inflammation, and cell proliferation. Its specific inhibition of PRAK makes it a valuable tool in scientific research to study the functions and roles of this kinase in various cellular processes.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
50 g
100 g
250 g
1 kg
5 kg
$33.00
$67.00
$97.00
$192.00
$775.00
13
(1)

Caffeine has been reported to inhibit PRK activity in certain cellular contexts.

Paullone

142273-18-5sc-208152
10 mg
$260.00
2
(0)

Certain paullone derivatives have been studied for their inhibitory effects on PRK and other kinases.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a well-known inhibitor of p38 MAPK, which can also affect PRK activity.

Luteolin

491-70-3sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$27.00
$51.00
$101.00
$153.00
$1925.00
40
(1)

Luteolin is a natural flavonoid compound that has been reported to inhibit PRK activity.

Doramapimod

285983-48-4sc-300502
sc-300502A
sc-300502B
25 mg
50 mg
100 mg
$149.00
$281.00
$459.00
2
(1)

BIRB 796 is a potent inhibitor of p38 MAPK, which can also affect PRK activity.

PKF118-310

84-82-2sc-364590
sc-364590A
5 mg
25 mg
$180.00
$651.00
(1)

PKF 118-310 is a pyrazolo[1,5-a]pyrimidine compound that has been studied for its inhibitory effects on PRK and other kinases.