Molecular structure of Paullone, CAS Number: 142273-18-5
Paullone (CAS 142273-18-5)
See product citations (2)
Application:
Paullone is a potent inhibitor of Cdk
CAS Number:
142273-18-5
Molecular Weight:
248.28
Molecular Formula:
C16H12N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A potent inhibitor of cyclin-dependent kinases (CDKs), which are involved in the regulation of the cell cycle.
Paullone (CAS 142273-18-5) References
- Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. | Schultz, C., et al. 1999. J Med Chem. 42: 2909-19. PMID: 10425100
- Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. | Lahusen, T., et al. 2003. Mol Carcinog. 36: 183-94. PMID: 12669310
- Structure-aided optimization of kinase inhibitors derived from alsterpaullone. | Kunick, C., et al. 2005. Chembiochem. 6: 541-9. PMID: 15696597
- Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). | Becker, A., et al. 2010. Eur J Med Chem. 45: 335-42. PMID: 19906467
- High-content screening assay-based discovery of paullones as novel podocyte-protective agents. | Lee, HW., et al. 2018. Am J Physiol Renal Physiol. 314: F280-F292. PMID: 29046299
- A Synthesis of Multifunctionalized Indoles from [3 + 2] Annulation of 2-Bromocyclopropenes with Anilines. | Cao, Z., et al. 2019. Org Lett. 21: 4097-4100. PMID: 31084023
- Fused-azepinones: Emerging scaffolds of medicinal importance. | Akunuri, R., et al. 2021. Eur J Med Chem. 220: 113445. PMID: 33901899
- Synthesis of 2-(2-nitrophenyl)indoline-3-acetic acid derivatives via base-catalyzed cyclization of N-(2-nitrobenzyl)-2-aminocinnamic acid derivatives. | Park, JH., et al. 2023. Org Biomol Chem. 21: 1647-1652. PMID: 36723252
- Cyclin-dependent kinase inhibitors and human cancer. | Kamb, A. 1998. Curr Top Microbiol Immunol. 227: 139-48. PMID: 9479829
Inhibitor of:
Cdk, Dyrk1A, and PRAK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paullone, 10 mg | sc-208152 | 10 mg | $260.00 |