PPP2R4 Inhibitors
The chemical class known as PPP2R4 inhibitors comprises a group of compounds that selectively target and modulate the activity of the protein phosphatase 2A regulatory subunit B (PPP2R4). PPP2R4 is an essential regulatory subunit of the protein phosphatase 2A (PP2A) enzyme, which plays a crucial role in the dephosphorylation of various cellular proteins involved in vital signaling pathways. By inhibiting PPP2R4, these compounds disrupt the interaction between PPP2R4 and PP2A, leading to altered PP2A activity and subsequent changes in cellular signaling and function.
PPP2R4 inhibitors can be of diverse chemical structures, including natural products and synthetic molecules, each with distinct modes of action and selectivity profiles. Extensive research on these inhibitors has shed light on the intricate mechanisms of PP2A regulation and its involvement in cellular processes, making them valuable tools in understanding cell biology and signaling cascades. Their precise roles in cellular contexts continue to be explored, with implications for various areas of basic science and drug discovery.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Originally developed as an immunosuppressive drug, FTY720 has been shown to inhibit PPP2R4, leading to altered cellular signaling pathways. It is primarily studied in the research of multiple sclerosis. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
A naturally occurring compound found in blister beetles, Cantharidin has been investigated for its potential to inhibit PPP2R4 and induce apoptosis in cancer cells. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Derived from marine dinoflagellates, Okadaic acid inhibits PPP2R4, leading to hyperphosphorylation of cellular proteins. It has been instrumental in studying the role of PP2A in various biological processes. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $113.00 | 2 | |
A derivative of Cantharidin, Norcantharidin has been studied for its potential anti-cancer properties, partially attributed to its ability to inhibit PPP2R4. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
A flavonoid found in various plants, luteolin has been investigated for its potential to inhibit PPP2R4 and modulate cellular processes. | ||||||
Diosgenin | 512-04-9 | sc-205652 sc-205652B sc-205652A | 5 g 25 g 100 g | $47.00 $131.00 $517.00 | 4 | |
A natural steroidal sapogenin, diosgenin has been studied for its inhibitory effects on PPP2R4, contributing to its potential therapeutic properties. | ||||||