PPP1R4 Activators
PPP1R4 Activators are a specialized group of chemical compounds that play a role in enhancing the functional activity of PPP1R4 through indirect modulation of various biochemical pathways. Forskolin, Dibutyryl-cAMP, and 8-Br-cAMP, through their ability to increase intracellular cAMP levels, activate protein kinase A (PKA), which can subsequently influence PPP1R4 activity by modifying its phosphorylation state. This modulation is crucial for PPP1R4's regulatory impact on protein phosphatase 1, which controls various cellular functions. Ionomycin and Thapsigargin work by increasing intracellular calcium concentrations, thereby activating calcium-dependent signaling mechanisms that can affect PPP1R4 activity. Phorbol 12-myristate 13-acetate (PMA) targets protein kinase C (PKC), which may also phosphorylate and alter PPP1R4 activity, similarly enhancing its role in regulating protein phosphatase 1.
Isoproterenol amplifies cAMP levels via beta-adrenergic receptor signaling, which can lead to PKA-mediated modulation of PPP1R4. Epigallocatechin gallate (EGCG), while known for its broad effects on signaling molecules, may intersect with pathways that modulate PP1 activity, thereby impacting PPP1R4's regulatory capacity. Anisomycin activates stress-activated protein kinases, which could alter signaling pathways relevant to PPP1R4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels which can activate PKA. PKA phosphorylation can lead to changes in the phosphorylation state of PPP1R4, potentially enhancing its protein phosphatase 1 regulatory activities. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. PKA can alter the function of PPP1R4 by phosphorylation, enhancing its regulatory role over protein phosphatase 1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which could activate calcium-sensitive signaling pathways that modulate the activity of PPP1R4. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which may phosphorylate and change the activity of PPP1R4, leading to altered regulation of protein phosphatase 1. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cAMP analog that activates PKA. Activation of PKA could lead to the enhancement of PPP1R4's role in modulating protein phosphatase 1 activities. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase cAMP levels, thereby activating PKA which may then influence the activity of PPP1R4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol that may influence various signaling pathways, including those that modulate PP1 activity. This could indirectly affect PPP1R4's regulatory role. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases, potentially influencing signaling pathways that affect PPP1R4's activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that raises intracellular calcium levels, affecting calcium-dependent signaling pathways and possibly PPP1R4's activity. | ||||||