PPP1R1C Activators

PPP1R1C activators predominantly function through the inhibition of protein phosphatase 2A (PP2A), thereby shifting enzymatic balance towards protein phosphatase 1 (PP1), where PPP1R1C serves as a regulatory subunit. Inhibition of PP2A is a common theme among chemicals such as Okadaic Acid, Calyculin A, and Endothall. By inhibiting PP2A, these compounds lead to an increase in PP1 activity, which directly influences PPP1R1C activity. Given that PP1 and PP2A often counteract each other in many cellular processes, inhibiting PP2A leads to an elevation of PP1 activity, and subsequently, PPP1R1C becomes activated as part of the PP1 complex.

Other mechanisms include alterations in cytoskeleton dynamics and intracellular localization, as observed with Nocodazole and Cytochalasin D. These compounds influence the subcellular localization of PP1, thereby affecting PPP1R1C as part of the PP1 complex. Also, some chemicals like Spermine and Zinc ions directly activate PP1, thereby influencing PPP1R1C activity. These mechanisms show that PPP1R1C activators are specific in their action, either promoting PP1 activity or altering cellular dynamics to ensure that PPP1R1C, as a subunit of PP1, is activated.