PPAR gamma Activators
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Items 11 to 20 of 51 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-Ibuprofen | 51146-56-6 | sc-200612 sc-200612A | 1 g 5 g | $47.00 $140.00 | 4 | |
(S)-Ibuprofen acts as a PPAR gamma modulator, showcasing a distinctive ability to interact with the receptor through selective binding sites. Its stereochemistry allows for enhanced affinity, leading to unique conformational shifts that optimize receptor activation. This compound influences downstream signaling cascades, modulating inflammatory responses and metabolic processes. Additionally, its kinetic profile suggests a rapid onset of action, followed by prolonged receptor engagement, contributing to its regulatory effects on cellular functions. | ||||||
T0070907 | 313516-66-4 | sc-203287 | 5 mg | $138.00 | 1 | |
An antagonist of PPARγ, inhibiting its activity by binding to the receptor and preventing activation. | ||||||
ETYA | 1191-85-1 | sc-200764 sc-200764A | 20 mg 100 mg | $75.00 $313.00 | 3 | |
ETYA functions as a PPAR gamma modulator, exhibiting a unique capacity for ligand-induced conformational changes that enhance receptor dimerization. Its structural characteristics facilitate specific interactions with coactivator proteins, promoting transcriptional activity. The compound's dynamic binding kinetics allow for a nuanced regulation of gene expression, influencing lipid metabolism and adipocyte differentiation. This intricate interplay underscores its role in cellular signaling pathways, highlighting its distinct biochemical behavior. | ||||||
Ciglitazone | 74772-77-3 | sc-200902 sc-200902A | 5 mg 25 mg | $102.00 $420.00 | 10 | |
Similar to rosiglitazone and pioglitazone, activates PPARγ by binding to the receptor, promoting gene expression associated with glucose and lipid regulation. | ||||||
Rosiglitazone (potassium salt) | 316371-84-3 | sc-205493 sc-205493A | 5 mg 10 mg | $45.00 $86.00 | 1 | |
Rosiglitazone (potassium salt) acts as a PPAR gamma agonist, engaging in selective binding that stabilizes the receptor's active conformation. This interaction promotes the recruitment of transcriptional coactivators, enhancing gene expression related to glucose and lipid homeostasis. Its unique affinity for the receptor allows for differential modulation of downstream signaling pathways, influencing metabolic processes. The compound's ability to fine-tune these interactions underscores its complex biochemical dynamics. | ||||||
LG 100754 | 180713-37-5 | sc-361231 sc-361231A | 5 mg 25 mg | $134.00 $544.00 | ||
LG 100754 functions as a PPAR gamma agonist, exhibiting a high degree of specificity in its binding interactions. This compound facilitates the conformational shift of the receptor, promoting a unique assembly of transcriptional complexes. Its kinetic profile reveals a rapid onset of action, allowing for swift modulation of gene expression linked to metabolic regulation. The distinct molecular interactions of LG 100754 highlight its role in orchestrating intricate cellular pathways, influencing lipid metabolism and insulin sensitivity. | ||||||
CAY10506 | 292615-75-9 | sc-221403 sc-221403A | 1 mg 5 mg | $53.00 $250.00 | ||
CAY10506 acts as a selective PPAR gamma modulator, engaging in unique hydrogen bonding and hydrophobic interactions that stabilize its binding to the receptor. This compound induces a distinct conformational change, enhancing the recruitment of coactivators and altering transcriptional dynamics. Its reaction kinetics demonstrate a gradual activation profile, allowing for sustained modulation of metabolic pathways. CAY10506's specific interactions underscore its role in fine-tuning cellular responses to metabolic stimuli. | ||||||
GQ-16 | 870554-67-9 | sc-364377 sc-364377A | 5 mg 10 mg | $51.00 $97.00 | ||
GQ-16 functions as a selective PPAR gamma modulator, characterized by its ability to form specific π-π stacking interactions with aromatic residues in the receptor. This compound promotes a unique allosteric effect, facilitating the recruitment of transcriptional coactivators while simultaneously inhibiting undesired pathways. Its kinetic profile reveals a rapid onset of action, followed by a prolonged engagement, allowing for nuanced regulation of gene expression related to lipid metabolism. | ||||||
Nateglinide | 105816-04-4 | sc-394067 sc-394067A | 10 mg 25 mg | $188.00 $260.00 | ||
While primarily an insulin secretagogue, nateglinide may have partial PPARγ agonistic effects, modulating PPARγ activity. | ||||||
Auraptene | 495-02-3 | sc-202477 sc-202477A | 5 mg 25 mg | $45.00 $60.00 | ||
Auraptene acts as a selective PPAR gamma modulator, exhibiting unique hydrophobic interactions with the receptor's ligand-binding domain. This compound enhances receptor dimerization, promoting a distinct conformational change that optimizes the binding of coactivators. Its reaction kinetics indicate a gradual activation, leading to sustained modulation of metabolic pathways. Additionally, Auraptene's structural features allow for specific interactions with surrounding amino acids, influencing downstream signaling cascades. | ||||||