Date published: 2025-10-16

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GQ-16 (CAS 870554-67-9)

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Alternate Names:
5Z- [(5- bromo- 2- methoxyphenyl)methylene]- 3- [(4- methylphenyl)methyl]- 2, 4- thiazolidinedione
Application:
GQ-16 is a partial agonist of PPARγ and an insulin sensitizer.
CAS Number:
870554-67-9
Molecular Weight:
418.30
Molecular Formula:
C19H16BrNO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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GQ-16 is known to interact with specific proteins and enzymes, affecting various cellular processes. GQ-16 modulates gene expression and signal transduction pathways, making it useful for studying molecular mechanisms in cells. GQ-16 has an impact on cell proliferation and differentiation, providing insights into the regulation of these fundamental biological processes. Its ability to target specific molecular pathways makes it an important compound for investigating the underlying mechanisms of various cellular functions. In biochemistry, GQ-16 is utilized to explored the network of molecular interactions within cells, ultimately contributing to a deeper understanding of cellular biology.


GQ-16 (CAS 870554-67-9) References

  1. Coupling of M3 acetylcholine receptor to Gq16 activates a natriuretic peptide receptor guanylyl cyclase.  |  Bruges, G., et al. 2007. J Recept Signal Transduct Res. 27: 189-216. PMID: 17613728
  2. GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.  |  Amato, AA., et al. 2012. J Biol Chem. 287: 28169-79. PMID: 22584573
  3. Effect of new thiazolidine derivatives LPSF/GQ-02 and LPSF/GQ-16 on atherosclerotic lesions in LDL receptor-deficient mice (LDLR(-/-)).  |  Soares E Silva, AK., et al. 2013. Cardiovasc Pathol. 22: 81-90. PMID: 22795892
  4. Structure-based identification of novel PPAR gamma ligands.  |  da Silva, FM., et al. 2013. Bioorg Med Chem Lett. 23: 5795-802. PMID: 24075729
  5. PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes.  |  Milton, FA., et al. 2015. Biochem Biophys Res Commun. 464: 718-23. PMID: 26168725
  6. GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice.  |  Coelho, MS., et al. 2016. PLoS One. 11: e0154310. PMID: 27138164
  7. PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells.  |  Li, J., et al. 2016. Vascul Pharmacol. 83: 90-7. PMID: 27235860
  8. CHARMM Force Field Parameterization of Peroxisome Proliferator-Activated Receptor γ Ligands.  |  Mottin, M., et al. 2016. Int J Mol Sci. 18: PMID: 28025495
  9. Identification of the anti-fungal drug fenticonazole nitrate as a novel PPARγ-modulating ligand with good therapeutic index: Structure-based screening and biological validation.  |  Ma, L., et al. 2021. Pharmacol Res. 173: 105860. PMID: 34461220
  10. Evaluation of the action of LPSF/GQ-16 on cytokines and PPAR-γ gene expression after in vitro irradiation of peripheral blood mononuclear cells.  |  Brayner Cavalcanti, M., et al. 2021. Int J Radiat Biol. 97: 1649-1656. PMID: 34586957
  11. Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome.  |  Bryant, C., et al. 2022. iScience. 25: 104001. PMID: 35310946
  12. Identification of Selective PPAR-γ Modulators by Combining Pharmacophore Modeling, Molecular Docking, and Adipogenesis Assay.  |  Li, Y., et al. 2023. Appl Biochem Biotechnol. 195: 1014-1041. PMID: 36264481
  13. Alternatively Spliced Landscape of PPARγ mRNA in Podocytes Is Distinct from Adipose Tissue.  |  Bryant, C., et al. 2022. Cells. 11: PMID: 36359851

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

GQ-16, 5 mg

sc-364377
5 mg
$51.00

GQ-16, 10 mg

sc-364377A
10 mg
$97.00