Molecular structure of Rosiglitazone (potassium salt), CAS Number: 316371-84-3
Rosiglitazone (potassium salt) (CAS 316371-84-3)
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Application:
Rosiglitazone (potassium salt) is a potent and selective PPARγ ligand
CAS Number:
316371-84-3
Purity:
>98%
Molecular Weight:
395.5
Molecular Formula:
C18H18N3O3S•K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rosiglitazone (potassium salt) is a PPARgamma (peroxisome proliferator-activated subtype gamma receptor) agonist which regulates the epithelial sodium channel (ENaC) and Na-K-2Cl (NKCC2) co-transporter. Studies have shown that NKCC2 is inhibited by down regulation of the genes that code for the protein. Further studies have shown that Rosiglitazone increases the abundance of the alpha subunit of ENaC but causes a decrease in the abundance of cortical beta- and gamma-ENaC.
Rosiglitazone (potassium salt) (CAS 316371-84-3) References
- Rosiglitazone regulates ENaC and Na-K-2Cl cotransporter (NKCC2) abundance in the obese Zucker rat. | Riazi, S., et al. 2006. Am J Nephrol. 26: 245-57. PMID: 16757903
- Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. | Tureyen, K., et al. 2007. J Neurochem. 101: 41-56. PMID: 17394460
- Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. | Zhao, X., et al. 2007. Ann Neurol. 61: 352-62. PMID: 17457822
- Thiazolidinedione drugs block cardiac KATP channels and may increase propensity for ischaemic ventricular fibrillation in pigs. | Lu, L., et al. 2008. Diabetologia. 51: 675-85. PMID: 18251006
- Activation of PPARgamma by rosiglitazone attenuates intestinal Cl- secretion. | Bajwa, PJ., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 297: G82-9. PMID: 19443733
- Rosiglitazone prevents sirolimus-induced hypomagnesemia, hypokalemia, and downregulation of NKCC2 protein expression. | da Silva, CA., et al. 2009. Am J Physiol Renal Physiol. 297: F916-22. PMID: 19656910
- Effect of rosiglitazone on cardiac electrophysiology, infarct size and mitochondrial function in ischaemia and reperfusion of swine and rat heart. | Palee, S., et al. 2011. Exp Physiol. 96: 778-89. PMID: 21666037
- Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. | Lumeng, CN., et al. 2011. J Immunol. 187: 6208-16. PMID: 22075699
- Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fibrillation in pigs. | Sarraf, M., et al. 2012. Cardiovasc Drugs Ther. 26: 195-204. PMID: 22450779
- Rosiglitazone attenuates hyperglycemia-enhanced hemorrhagic transformation after transient focal ischemia in rats. | Zhang, FH., et al. 2013. Neuroscience. 250: 651-7. PMID: 23892005
- Expression regulation and targeting of the peroxisome proliferator-activated receptor γ following electrically-induced status epilepticus. | Boes, K., et al. 2015. Neurosci Lett. 604: 151-6. PMID: 26259695
- Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors. | Guo, M., et al. 2017. Mol Psychiatry. 22: 1056-1068. PMID: 27956741
- Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage. | Chang, CF., et al. 2017. Neurobiol Dis. 103: 54-69. PMID: 28365213
- Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor trihybrids for improving glucose tolerance. | Liu, J., et al. 2019. Eur J Med Chem. 162: 650-665. PMID: 30481687
- Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. | Kobayashi, T., et al. 2020. Blood. 136: 3004-3017. PMID: 32818230
Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rosiglitazone (potassium salt), 5 mg | sc-205493 | 5 mg | $45.00 | |||
Rosiglitazone (potassium salt), 10 mg | sc-205493A | 10 mg | $86.00 |