PP2Cκ Activators
PP2Cκ, also known as Protein Phosphatase 2C kappa, is a member of the PP2C family of protein phosphatases, encoded by the PP2Cκ gene. It plays a crucial role in cellular signaling pathways by dephosphorylating specific substrates, thereby regulating their activity and cellular functions. As a phosphatase, PP2Cκ primarily functions to counterbalance the actions of protein kinases, which phosphorylate proteins to modulate their activity. By removing phosphate groups from proteins, PP2Cκ serves as a negative regulator of signaling pathways involved in various cellular processes, including cell proliferation, differentiation, and stress response. Through its phosphatase activity, PP2Cκ acts as a key modulator of intracellular signaling cascades, ensuring proper cellular responses to external stimuli and maintaining cellular homeostasis.
Activation of PP2Cκ involves mechanisms aimed at enhancing its phosphatase activity, thereby promoting the dephosphorylation of substrate proteins and modulating downstream signaling events. One common mechanism of activation is the binding of specific activator proteins or cofactors to PP2Cκ, leading to conformational changes that increase its catalytic efficiency or substrate specificity. Additionally, post-translational modifications such as phosphorylation or acetylation may regulate PP2Cκ activity, enhancing its ability to interact with substrate proteins and exert its phosphatase function. Furthermore, changes in subcellular localization or expression levels of PP2Cκ may also contribute to its activation, allowing for precise temporal and spatial regulation of its phosphatase activity in response to cellular stimuli. Understanding the mechanisms of PP2Cκ activation is crucial for deciphering its role in cellular signaling networks and may provide insights into the development of interventions targeting dysregulated signaling pathways associated with disease states.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator. The activation of JNK can lead to the activation of pathways that PP2Cκ is involved in, enhancing its functional activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a PKA inhibitor. By inhibiting PKA, H-89 could potentially enhance the functional activity of PP2Cκ by reducing the phosphorylation of substrates that may inhibit the pathways PP2Cκ is involved in. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is a selective and potent inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). By inhibiting CaMKII, KN-62 can potentially modify the signaling pathways that PP2Cκ is involved in, leading to an increase in its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. By inhibiting mTOR, rapamycin can potentially modify the signaling pathways that PP2Cκ is involved in, leading to an increase in its functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and selective inhibitor of PI3K. By inhibiting PI3K, wortmannin can potentially modify the signaling pathways that PP2Cκ is involved in, leading to an increase in its functional activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor. By inhibiting ROCK, Y-27632 can potentially modify the signaling pathways that PP2Cκ is involved in, leading to an increase in its functional activity. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $57.00 $101.00 | 9 | |
Trifluoperazine is a calmodulin inhibitor. By inhibiting calmodulin, trifluoperazine can potentially modify the signaling pathways that PP2Cκ is involved in, leading to an increase in its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore. By increasing intracellular calcium levels, A23187 can potentially modify the signaling pathways that PP2Cκ is involved in, leading to an increase in its functional activity. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Go6976 is a PKC inhibitor. By inhibiting PKC, Go6976 can potentially modify the signaling pathways that PP2Cκ is involved in, leading to an increase in its functional activity. | ||||||